Abstract
Background: The mechanism for production of N2O3 from MetHb, nitrite, and NO is controversial. Results: An Hb intermediate attributed to heme-bound N2O3 is characterized. Conclusion: Partially met-R state Hb can function as a generator of long lived forms of bioactive NO. Significance: The results provide insight into how Hb reactivity with nitrite can be harnessed physiologically and therapeutically.
Original language | English (US) |
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Pages (from-to) | 22408-22425 |
Number of pages | 18 |
Journal | Journal of Biological Chemistry |
Volume | 288 |
Issue number | 31 |
DOIs | |
State | Published - Aug 2 2013 |
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Cell Biology