Generating S-nitrosothiols from hemoglobin: Mechanisms, conformational dependence, and physiological relevance

Camille J. Roche, Maria B. Cassera, David Dantsker, Rhoda Elison Hirsch, Joel M. Friedman

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

Background: The mechanism for production of N2O3 from MetHb, nitrite, and NO is controversial. Results: An Hb intermediate attributed to heme-bound N2O3 is characterized. Conclusion: Partially met-R state Hb can function as a generator of long lived forms of bioactive NO. Significance: The results provide insight into how Hb reactivity with nitrite can be harnessed physiologically and therapeutically.

Original languageEnglish (US)
Pages (from-to)22408-22425
Number of pages18
JournalJournal of Biological Chemistry
Volume288
Issue number31
DOIs
StatePublished - Aug 2 2013

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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