Background: The mechanism for production of N2O3 from MetHb, nitrite, and NO is controversial. Results: An Hb intermediate attributed to heme-bound N2O3 is characterized. Conclusion: Partially met-R state Hb can function as a generator of long lived forms of bioactive NO. Significance: The results provide insight into how Hb reactivity with nitrite can be harnessed physiologically and therapeutically.
|Original language||English (US)|
|Number of pages||18|
|Journal||Journal of Biological Chemistry|
|State||Published - Aug 2 2013|
ASJC Scopus subject areas
- Molecular Biology
- Cell Biology