General aspects of anti-angiogenesis and cancer therapy

Theresa G. Zogakis, Steven K. Libutti

Research output: Contribution to journalArticlepeer-review

44 Scopus citations

Abstract

Angiogenesis is the outgrowth of new vessels from pre-existing ones. Tumour growth and metastasis is dependent on angiogenesis and many stimulatory and inhibitory factors have been described which play an active role in this process. Inhibition of tumour neovasculature may be one strategy to inhibit tumour growth. Naturally occurring inhibitors of angiogenesis have been discovered and synthetic agents have been designed. Many of these inhibitors are currently being evaluated in clinical trials for the treatment of cancer. This review discusses the mechanism of action of these anti-angiogenics as well as a description of the clinical trials in which they are being evaluated. 2001 Ashley Publications Ltd Papers of special note have been highlighted as: • of interest •• of considerable interest.

Original languageEnglish (US)
Pages (from-to)253-275
Number of pages23
JournalExpert opinion on biological therapy
Volume1
Issue number2
DOIs
StatePublished - Jan 1 2001

Keywords

  • Angiogenesis
  • Cancer therapy
  • Carboxyamido-triazole
  • Endostatin
  • IL-12
  • Matrix metalloproteinases
  • Sitramin
  • Thalidomide
  • VEGF

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery
  • Clinical Biochemistry

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