Gene therapy for head and neck cancer

Waleed M. Abuzeid, Daqing Li, Bert W. O'Malley

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Citations (Scopus)

Abstract

The mortality associated with head and neck cancer has remained largely unchanged for the past several decades despite advancements in surgery, radiotherapy and chemotherapy. Gene therapy is a novel treatment approach that may potentially advance the treatment of genetic diseases, which include malignancies such as head and neck cancer. Multiple vector systems have been developed that facilitate the introduction of therapeutic genetic material into cells. These include DNA-based vectors, viral vectors and, most recently, vectors that induce RNA interference. Gene therapy strategies can be classified in 3 groups: (1) cytoreductive therapy aimed at directly inducing cell death, (2) corrective therapy intended to repair genetic defects underlying malignancy, and (3) immune modulation to promote a robust immune response against cancer. Cells. Translational research has been conducted in each of these areas, culminating in clinical trials and the implementation of gene therapy as a viable therapeutic modality for head and neck cancers.

Original languageEnglish (US)
Title of host publicationAdvances in Oto-Rhino-Laryngology
Pages141-151
Number of pages11
Volume70
DOIs
StatePublished - 2011
Externally publishedYes

Publication series

NameAdvances in Oto-Rhino-Laryngology
Volume70
ISSN (Print)00653071

Fingerprint

gene therapy
Gene therapy
Head and Neck Neoplasms
Genetic Therapy
cancer
Chemotherapy
Radiotherapy
Cell death
Therapeutics
Surgery
surgery
interference
Neoplasms
Inborn Genetic Diseases
Repair
Translational Medical Research
mortality
Modulation
RNA
RNA Interference

ASJC Scopus subject areas

  • Otorhinolaryngology
  • Arts and Humanities(all)
  • Social Sciences(all)
  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Abuzeid, W. M., Li, D., & O'Malley, B. W. (2011). Gene therapy for head and neck cancer. In Advances in Oto-Rhino-Laryngology (Vol. 70, pp. 141-151). (Advances in Oto-Rhino-Laryngology; Vol. 70). https://doi.org/10.1159/000322490

Gene therapy for head and neck cancer. / Abuzeid, Waleed M.; Li, Daqing; O'Malley, Bert W.

Advances in Oto-Rhino-Laryngology. Vol. 70 2011. p. 141-151 (Advances in Oto-Rhino-Laryngology; Vol. 70).

Research output: Chapter in Book/Report/Conference proceedingChapter

Abuzeid, WM, Li, D & O'Malley, BW 2011, Gene therapy for head and neck cancer. in Advances in Oto-Rhino-Laryngology. vol. 70, Advances in Oto-Rhino-Laryngology, vol. 70, pp. 141-151. https://doi.org/10.1159/000322490
Abuzeid WM, Li D, O'Malley BW. Gene therapy for head and neck cancer. In Advances in Oto-Rhino-Laryngology. Vol. 70. 2011. p. 141-151. (Advances in Oto-Rhino-Laryngology). https://doi.org/10.1159/000322490
Abuzeid, Waleed M. ; Li, Daqing ; O'Malley, Bert W. / Gene therapy for head and neck cancer. Advances in Oto-Rhino-Laryngology. Vol. 70 2011. pp. 141-151 (Advances in Oto-Rhino-Laryngology).
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