Gene therapy for head and neck cancer

Waleed M. Abuzeid, Daqing Li, Bert W. O'Malley

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Scopus citations

Abstract

The mortality associated with head and neck cancer has remained largely unchanged for the past several decades despite advancements in surgery, radiotherapy and chemotherapy. Gene therapy is a novel treatment approach that may potentially advance the treatment of genetic diseases, which include malignancies such as head and neck cancer. Multiple vector systems have been developed that facilitate the introduction of therapeutic genetic material into cells. These include DNA-based vectors, viral vectors and, most recently, vectors that induce RNA interference. Gene therapy strategies can be classified in 3 groups: (1) cytoreductive therapy aimed at directly inducing cell death, (2) corrective therapy intended to repair genetic defects underlying malignancy, and (3) immune modulation to promote a robust immune response against cancer. Cells. Translational research has been conducted in each of these areas, culminating in clinical trials and the implementation of gene therapy as a viable therapeutic modality for head and neck cancers.

Original languageEnglish (US)
Title of host publicationMedical Genetics in the Clinical Practice of ORL
EditorsRaye Alford, Reid Sutton
Pages141-151
Number of pages11
DOIs
StatePublished - Mar 14 2011
Externally publishedYes

Publication series

NameAdvances in Oto-Rhino-Laryngology
Volume70
ISSN (Print)0065-3071

ASJC Scopus subject areas

  • Otorhinolaryngology

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  • Cite this

    Abuzeid, W. M., Li, D., & O'Malley, B. W. (2011). Gene therapy for head and neck cancer. In R. Alford, & R. Sutton (Eds.), Medical Genetics in the Clinical Practice of ORL (pp. 141-151). (Advances in Oto-Rhino-Laryngology; Vol. 70). https://doi.org/10.1159/000322490