Gene targeting in mammalian cells by homologous recombination

Bernice Morrow, Raju Kucherlapati

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Gene targeting by homologous recombination is a genetic tool that permits modification of cellular genes in a precise and predetermined fashion. The methodologies that are currently available permit gene targeting at high efficiency and fidelity. New developments promise large-scale modification of the mammalian genome using these techniques.

Original languageEnglish (US)
Pages (from-to)577-582
Number of pages6
JournalCurrent Opinion in Biotechnology
Volume4
Issue number5
DOIs
Publication statusPublished - Oct 1993

    Fingerprint

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Biomedical Engineering

Cite this