Gene-target recognition among members of the Myc superfamily and implications for oncogenesis

Rónán C. O'Hagan, Nicole Schreiber-Agus, Ken Chen, Gregory David, Jeffrey A. Engelman, Richard Schwab, Leila Alland, Cole Thomson, Donald R. Ronning, James C. Sacchettini, Paul Meltzer, Ronald A. DePinho

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118 Scopus citations

Abstract

Myc and Mad family proteins regulate multiple biological processes through their capacity to influence gene expression directly. Here we show that the basic regions of Myc and Mad proteins are not functionally equivalent in oncogenesis, have separable E-box-binding activities and engage both common and distinct gene targets. Our data support the view that the opposing biological actions of Myc and Mxi1 extend beyond reciprocal regulation of common gene targets. Identification of differentially regulated gene targets provides a framework for understanding the mechanism through which the Myc superfamily governs the growth, proliferation and survival of normal and neoplastic cells.

Original languageEnglish (US)
Pages (from-to)113-119
Number of pages7
JournalNature Genetics
Volume24
Issue number2
DOIs
StatePublished - Feb 1 2000

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ASJC Scopus subject areas

  • Genetics

Cite this

O'Hagan, R. C., Schreiber-Agus, N., Chen, K., David, G., Engelman, J. A., Schwab, R., Alland, L., Thomson, C., Ronning, D. R., Sacchettini, J. C., Meltzer, P., & DePinho, R. A. (2000). Gene-target recognition among members of the Myc superfamily and implications for oncogenesis. Nature Genetics, 24(2), 113-119. https://doi.org/10.1038/72761