Gene regulation: The HSP70 gene jumps when shocked

Maria Vera; Robert H. Singer

doi:10.1016/j.cub.2014.03.070

Gene regulation: The HSP70 gene jumps when shocked

Maria Vera, Robert H. Singer

Research output: Contribution to journal › Short survey › peer-review

3 Scopus citations

Abstract

Limited chromosome mobility has been observed in mammalian interphase nuclei. Live imaging shows unidirectional and actin-dependent movement of HSP70 loci towards speckles upon heat shock, resulting in enhanced transcription. This adds further impetus to understanding compartmentalization of function in the nucleus.

Original language	English (US)
Pages (from-to)	R396-R398
Journal	Current Biology
Volume	24
Issue number	10
DOIs	https://doi.org/10.1016/j.cub.2014.03.070
State	Published - May 19 2014

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology
General Agricultural and Biological Sciences

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title = "Gene regulation: The HSP70 gene jumps when shocked",

abstract = "Limited chromosome mobility has been observed in mammalian interphase nuclei. Live imaging shows unidirectional and actin-dependent movement of HSP70 loci towards speckles upon heat shock, resulting in enhanced transcription. This adds further impetus to understanding compartmentalization of function in the nucleus.",

author = "Maria Vera and Singer, {Robert H.}",

year = "2014",

month = may,

day = "19",

doi = "10.1016/j.cub.2014.03.070",

language = "English (US)",

volume = "24",

pages = "R396--R398",

journal = "Current Biology",

issn = "0960-9822",

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TY - JOUR

T1 - Gene regulation

T2 - The HSP70 gene jumps when shocked

AU - Vera, Maria

AU - Singer, Robert H.

PY - 2014/5/19

Y1 - 2014/5/19

N2 - Limited chromosome mobility has been observed in mammalian interphase nuclei. Live imaging shows unidirectional and actin-dependent movement of HSP70 loci towards speckles upon heat shock, resulting in enhanced transcription. This adds further impetus to understanding compartmentalization of function in the nucleus.

AB - Limited chromosome mobility has been observed in mammalian interphase nuclei. Live imaging shows unidirectional and actin-dependent movement of HSP70 loci towards speckles upon heat shock, resulting in enhanced transcription. This adds further impetus to understanding compartmentalization of function in the nucleus.

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U2 - 10.1016/j.cub.2014.03.070

DO - 10.1016/j.cub.2014.03.070

M3 - Short survey

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AN - SCOPUS:84901064636

SN - 0960-9822

VL - 24

SP - R396-R398

JO - Current Biology

JF - Current Biology

IS - 10

ER -

Gene regulation: The HSP70 gene jumps when shocked

Abstract

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