Gene regulation

The HSP70 gene jumps when shocked

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Limited chromosome mobility has been observed in mammalian interphase nuclei. Live imaging shows unidirectional and actin-dependent movement of HSP70 loci towards speckles upon heat shock, resulting in enhanced transcription. This adds further impetus to understanding compartmentalization of function in the nucleus.

Original languageEnglish (US)
JournalCurrent Biology
Volume24
Issue number10
DOIs
StatePublished - May 19 2014

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Interphase
Transcription
Chromosomes
Speckle
Gene expression
interphase
actin
heat stress
Actins
Shock
transcription (genetics)
Hot Temperature
Genes
image analysis
chromosomes
Imaging techniques
loci
genes

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Gene regulation : The HSP70 gene jumps when shocked. / Vera Ugalde, Maria; Singer, Robert H.

In: Current Biology, Vol. 24, No. 10, 19.05.2014.

Research output: Contribution to journalArticle

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