Gene regulation by growth hormone

Peter Rotwein, Dennis J. Chia

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Since the somatomedin hypothesis of growth hormone (GH) action was first formulated more than 50 years ago, the key roles of both GH and insulin-like growth factor-I (IGF-I) in human growth have been extended to include important effects on tissue maintenance and repair. More recent observations have revealed that this pathway has a negative side, as it has been implicated as a potential contributor to the development of several human cancers and has been linked to diminished lifespan in experimental animals. This brief review focuses on fundamental aspects of gene regulation by GH, as long-term hormonal effects all require changes in gene expression. Topics to be discussed include GH-stimulated signal transduction pathways, mechanisms of gene activation and gene repression by GH, and an analysis of control of IGF-I gene transcription by the GH-stimulated transcription factor, signal transducer and activator of transcription (Stat)5b.

Original languageEnglish (US)
Pages (from-to)651-658
Number of pages8
JournalPediatric Nephrology
Volume25
Issue number4
DOIs
StatePublished - Apr 2010
Externally publishedYes

Fingerprint

Growth Hormone
Genes
Insulin-Like Growth Factor I
STAT5 Transcription Factor
Human Development
Somatomedins
Transcriptional Activation
Signal Transduction
Transcription Factors
Maintenance
Gene Expression
Growth
Neoplasms

Keywords

  • Gene transcription
  • GH
  • Growth hormone
  • Growth regulation
  • IGF-I
  • Insulin-like growth factor-I
  • Stat
  • Stat5b

ASJC Scopus subject areas

  • Nephrology
  • Pediatrics, Perinatology, and Child Health

Cite this

Gene regulation by growth hormone. / Rotwein, Peter; Chia, Dennis J.

In: Pediatric Nephrology, Vol. 25, No. 4, 04.2010, p. 651-658.

Research output: Contribution to journalArticle

Rotwein, P & Chia, DJ 2010, 'Gene regulation by growth hormone', Pediatric Nephrology, vol. 25, no. 4, pp. 651-658. https://doi.org/10.1007/s00467-009-1258-y
Rotwein, Peter ; Chia, Dennis J. / Gene regulation by growth hormone. In: Pediatric Nephrology. 2010 ; Vol. 25, No. 4. pp. 651-658.
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