Gene rearrangements testing

Siby Sebastian; Juan Du; Rizwan Naeem

doi:10.1007/978-1-4614-2170-2_17

Gene rearrangements testing

Siby Sebastian, Juan Du, Rizwan Naeem

Pathology

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

The B- and T-cell gene rearrangement test is one of the hallmarks of the molecular pathology diagnostic laboratories. Historically done with Southern blot and now adopted by many laboratories using PCR, the test is used as an aid in pathology diagnosis to distinguish between benign lymphoproliferative disorders, usually polyclonal, and clonally derived cell populations seen in malignant cell population. Clonally amplified gene rearrangements can be used for diagnosis and as tumor-specific markers to monitor recurrence.

Original language	English (US)
Title of host publication	Modern Clinical Molecular Techniques
Publisher	Springer New York
Pages	245-259
Number of pages	15
Volume	9781461421702
ISBN (Electronic)	9781461421702
ISBN (Print)	1461421691, 9781461421696
DOIs	https://doi.org/10.1007/978-1-4614-2170-2_17
State	Published - Jul 1 2012

Keywords

B-cell gene rearrangement
Gene rearrangement
IgH
IgK
IgL
Monoclonality
T-cell lymphoma
T-cell monoclonality
TCR gamma gene

ASJC Scopus subject areas

Medicine(all)

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10.1007/978-1-4614-2170-2_17

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keywords = "B-cell gene rearrangement, Gene rearrangement, IgH, IgK, IgL, Monoclonality, T-cell lymphoma, T-cell monoclonality, TCR gamma gene",

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AB - The B- and T-cell gene rearrangement test is one of the hallmarks of the molecular pathology diagnostic laboratories. Historically done with Southern blot and now adopted by many laboratories using PCR, the test is used as an aid in pathology diagnosis to distinguish between benign lymphoproliferative disorders, usually polyclonal, and clonally derived cell populations seen in malignant cell population. Clonally amplified gene rearrangements can be used for diagnosis and as tumor-specific markers to monitor recurrence.

KW - B-cell gene rearrangement

KW - Gene rearrangement

KW - IgH

KW - IgK

KW - IgL

KW - Monoclonality

KW - T-cell lymphoma

KW - T-cell monoclonality

KW - TCR gamma gene

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ER -

Gene rearrangements testing

Abstract

Keywords

ASJC Scopus subject areas

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