Gene rearrangements testing

Siby Sebastian, Juan Du, Rizwan Naeem

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The B- and T-cell gene rearrangement test is one of the hallmarks of the molecular pathology diagnostic laboratories. Historically done with Southern blot and now adopted by many laboratories using PCR, the test is used as an aid in pathology diagnosis to distinguish between benign lymphoproliferative disorders, usually polyclonal, and clonally derived cell populations seen in malignant cell population. Clonally amplified gene rearrangements can be used for diagnosis and as tumor-specific markers to monitor recurrence.

Original languageEnglish (US)
Title of host publicationModern Clinical Molecular Techniques
PublisherSpringer New York
Pages245-259
Number of pages15
Volume9781461421702
ISBN (Electronic)9781461421702
ISBN (Print)1461421691, 9781461421696
DOIs
StatePublished - Jul 1 2012

Keywords

  • B-cell gene rearrangement
  • Gene rearrangement
  • IgH
  • IgK
  • IgL
  • Monoclonality
  • T-cell lymphoma
  • T-cell monoclonality
  • TCR gamma gene

ASJC Scopus subject areas

  • Medicine(all)

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  • Cite this

    Sebastian, S., Du, J., & Naeem, R. (2012). Gene rearrangements testing. In Modern Clinical Molecular Techniques (Vol. 9781461421702, pp. 245-259). Springer New York. https://doi.org/10.1007/978-1-4614-2170-2-17