Gene polymorphisms and transplantation

E. Akalin, B. Murphy

Research output: Contribution to journalReview article

70 Scopus citations

Abstract

The influence of gene polymorphisms in key immunoregulatory molecules on the clinical course post-transplant has become an area of active research, since it offers a possible explanation for the heterogeneity in outcomes between individuals. Several groups have now investigated the association of polymorphisms in molecules - including cytokines, cytokine receptors, adhesion molecules and costimulatory molecules - that participate in the immune response to an allograft. Several interesting observations have been made that would suggest that genetic variability influencing allograft survival reaches beyond that of the MHC molecules.

Original languageEnglish (US)
Pages (from-to)572-576
Number of pages5
JournalCurrent Opinion in Immunology
Volume13
Issue number5
DOIs
Publication statusPublished - Oct 1 2001
Externally publishedYes

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ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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