Gene polymorphisms and transplantation

E. Akalin, B. Murphy

Research output: Contribution to journalReview articlepeer-review

75 Scopus citations


The influence of gene polymorphisms in key immunoregulatory molecules on the clinical course post-transplant has become an area of active research, since it offers a possible explanation for the heterogeneity in outcomes between individuals. Several groups have now investigated the association of polymorphisms in molecules - including cytokines, cytokine receptors, adhesion molecules and costimulatory molecules - that participate in the immune response to an allograft. Several interesting observations have been made that would suggest that genetic variability influencing allograft survival reaches beyond that of the MHC molecules.

Original languageEnglish (US)
Pages (from-to)572-576
Number of pages5
JournalCurrent Opinion in Immunology
Issue number5
StatePublished - Oct 1 2001
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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