Gender Issues in Chronic Kidney Disease

Joel Neugarten, Jane F. Reckelhoff

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Abstract

Gender influences the incidence, prevalence and progression of CKD. In numerous experimental models of renal disease, progression is accelerated in male animals. This disparity in the course of renal disease is replicated by hormonal manipulation, suggesting that the actions of sex hormones, rather than structural differences between the sexes, are responsible for gender dimorphism in renal disease progression. Selective estrogen receptor modulators, which lack the detrimental effects of estrogen on reproductive tissue, have a beneficial effect on the course of CKD in animal models. Sex hormones influence many of the processes known to mediate progressive renal injury including cell proliferation, mesangial matrix synthesis and degradation, generation of reactive oxygen species as well as expression of pro-fibrotic pro-inflammatory cytokines, hormones and vasoactive agents. In humans the progression of non-diabetic and diabetes-related chronic kidney disease is arguably more rapid in men than in women, a finding which parallels observations in experimental animals.

Original languageEnglish (US)
Title of host publicationChronic Renal Disease
PublisherElsevier Inc.
Pages69-80
Number of pages12
ISBN (Print)9780124116160, 9780124116023
DOIs
StatePublished - Sep 24 2014

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Interpersonal Relations
Chronic Renal Insufficiency
Kidney
Gonadal Steroid Hormones
Disease Progression
Safe Sex
Selective Estrogen Receptor Modulators
Sex Characteristics
Reactive Oxygen Species
Estrogens
Theoretical Models
Animal Models
Cell Proliferation
Hormones
Cytokines
Incidence
Wounds and Injuries

Keywords

  • Chronic kidney disease
  • Estrogen
  • Gender
  • Sex
  • Testosterone

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Neugarten, J., & Reckelhoff, J. F. (2014). Gender Issues in Chronic Kidney Disease. In Chronic Renal Disease (pp. 69-80). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-411602-3.00007-X

Gender Issues in Chronic Kidney Disease. / Neugarten, Joel; Reckelhoff, Jane F.

Chronic Renal Disease. Elsevier Inc., 2014. p. 69-80.

Research output: Chapter in Book/Report/Conference proceedingChapter

Neugarten, J & Reckelhoff, JF 2014, Gender Issues in Chronic Kidney Disease. in Chronic Renal Disease. Elsevier Inc., pp. 69-80. https://doi.org/10.1016/B978-0-12-411602-3.00007-X
Neugarten J, Reckelhoff JF. Gender Issues in Chronic Kidney Disease. In Chronic Renal Disease. Elsevier Inc. 2014. p. 69-80 https://doi.org/10.1016/B978-0-12-411602-3.00007-X
Neugarten, Joel ; Reckelhoff, Jane F. / Gender Issues in Chronic Kidney Disease. Chronic Renal Disease. Elsevier Inc., 2014. pp. 69-80
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