TY - JOUR
T1 - Gender differences in lymphocyte populations, plasma HIV RNA levels, and disease progression in a cohort of children born to women infected with HIV
AU - Foca, Marc
AU - Moye, Jack
AU - Chu, Clara
AU - Matthews, Yvonne
AU - Rich, Ken
AU - Handelsman, Ed
AU - Luzuriaga, Katherine
AU - Paul, Mary
AU - Diaz, Clemente
AU - Pacheco-Acosta, Edna
AU - Tuomala, Ruth
AU - Cooper, Ellen
AU - Mesthene, Donna
AU - LaRussa, Phil
AU - Higgins, Alice
AU - Landesman, Sheldon
AU - Handelsman, Edward
AU - Dennie, Ava
AU - Rich, Kenneth
AU - Turpin, Delmyra
AU - Shearer, William
AU - Pacheco, Susan
AU - Cooper, Norma
AU - Rosario, Joana
AU - Nugent, Robert
AU - Smeriglio, Vincent
AU - Davenny, Katherine
AU - Thompson, Bruce
PY - 2006/7
Y1 - 2006/7
N2 - OBJECTIVE.We sought to document gender differences in lymphocyte subsets and plasma RNA levels in a pediatric cohort with presumed minimal hormonal differences (on the basis of age). METHODS. Blood samples from antiretroviral therapy-treated, HIV-infected children (n = 158) and HIV-uninfected children (n = 1801) who were enrolled in the Women and Infants Transmission Study were analyzed at specified study intervals with consensus protocols, and various parameters were compared. RESULTS. Antiretroviral therapy-treated, HIV-infected female children had, on average, 0.38 log10 copies per mL lower plasma RNA levels than did their male counterparts, but lymphocyte differences were not noted in this cohort. Despite their higher plasma RNA level, a greater proportion of male children survived through 8 years of age. There were no gender differences with respect to the age of diagnosis of HIV, time to antiretroviral therapy after diagnosis of HIV, or type of antiretroviral therapy. Lymphocyte differences were noted for uninfected children. CONCLUSIONS. Plasma RNA levels differed among antiretroviral therapy-treated, HIV-infected children according to gender, in a manner similar to that noted in previous pediatric and adult studies. Lymphocyte subsets varied according to gender in a cohort of HIV-exposed but uninfected children. Most importantly, overall mortality rates for this cohort differed according to gender.
AB - OBJECTIVE.We sought to document gender differences in lymphocyte subsets and plasma RNA levels in a pediatric cohort with presumed minimal hormonal differences (on the basis of age). METHODS. Blood samples from antiretroviral therapy-treated, HIV-infected children (n = 158) and HIV-uninfected children (n = 1801) who were enrolled in the Women and Infants Transmission Study were analyzed at specified study intervals with consensus protocols, and various parameters were compared. RESULTS. Antiretroviral therapy-treated, HIV-infected female children had, on average, 0.38 log10 copies per mL lower plasma RNA levels than did their male counterparts, but lymphocyte differences were not noted in this cohort. Despite their higher plasma RNA level, a greater proportion of male children survived through 8 years of age. There were no gender differences with respect to the age of diagnosis of HIV, time to antiretroviral therapy after diagnosis of HIV, or type of antiretroviral therapy. Lymphocyte differences were noted for uninfected children. CONCLUSIONS. Plasma RNA levels differed among antiretroviral therapy-treated, HIV-infected children according to gender, in a manner similar to that noted in previous pediatric and adult studies. Lymphocyte subsets varied according to gender in a cohort of HIV-exposed but uninfected children. Most importantly, overall mortality rates for this cohort differed according to gender.
KW - Gender
KW - HIV
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U2 - 10.1542/peds.2005-0294
DO - 10.1542/peds.2005-0294
M3 - Article
C2 - 16818560
AN - SCOPUS:33746857806
SN - 0031-4005
VL - 118
SP - 146
EP - 155
JO - Pediatrics
JF - Pediatrics
IS - 1
ER -