Gender-dependent mechanisms of injury and repair

Joel Neugarten; Ladan Golestaneh

doi:10.1016/B978-0-12-823318-4.00023-8

Gender-dependent mechanisms of injury and repair

Joel Neugarten, Ladan Golestaneh

Medicine

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

This chapter explores the role that sex hormones play in the development and progression of renal disease. Possible pathogenic mechanisms are described including the effects of sex hormones on cell biology and on the synthesis and release of vasoactive factors and inflammatory and profibrotic cytokines. Next, the role of sex hormones in influencing repair and regeneration following renal injury is discussed and possible pathogenic mechanisms explored. In light of the paucity of data that examine interactions between sex hormones and regeneration in the kidney, this chapter also draws on data which examine the role of sex hormones in the regeneration of nonrenal tissue to suggest avenues for future translational research involving the kidney.

Original language	English (US)
Title of host publication	Regenerative Nephrology
Publisher	Elsevier
Pages	303-318
Number of pages	16
ISBN (Electronic)	9780128233184
DOIs	https://doi.org/10.1016/B978-0-12-823318-4.00023-8
State	Published - Jan 1 2021

Keywords

Estrogen
Gender
Kidney
Regeneration
Sex
Testosterone

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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10.1016/B978-0-12-823318-4.00023-8

Cite this

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AB - This chapter explores the role that sex hormones play in the development and progression of renal disease. Possible pathogenic mechanisms are described including the effects of sex hormones on cell biology and on the synthesis and release of vasoactive factors and inflammatory and profibrotic cytokines. Next, the role of sex hormones in influencing repair and regeneration following renal injury is discussed and possible pathogenic mechanisms explored. In light of the paucity of data that examine interactions between sex hormones and regeneration in the kidney, this chapter also draws on data which examine the role of sex hormones in the regeneration of nonrenal tissue to suggest avenues for future translational research involving the kidney.

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Gender-dependent mechanisms of injury and repair

Abstract

Keywords

ASJC Scopus subject areas

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