Gender and the prevalence and progression of renal disease

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

In most experimental models of CKD, male animals progress more rapidly than females. Modulation of the hormonal milieu can replicate the effects of gender on the course of kidney disease. These observations suggest that sex hormones per se may be important determinants of the greater susceptibility of males to progressive kidney injury. The predominance of data in humans suggests that the course of nondiabetic kidney disease is more aggressive in men than women. Male gender is arguably also a risk factor for progression of diabetic nephropathy. Sex hormones directly or indirectly affect many cellular processes by modulating the synthesis of various cytokines, growth factors, and vasoactive agents. In particular, estrogen acts in a receptor-dependent mechanism to regulate genes involved in extracellular matrix metabolism. Estrogen has profound effects on transforming growth factor-β signal transduction and on the renin-angiotensin system. These effects may contribute to alterations in kidney hemodynamics and affect kidney disease progression. Selective estrogen receptor modulators, agents that mimic many of the beneficial effects of estrogen without reproducing estrogen's deleterious effects on reproductive tissue, ameliorate the course of kidney disease in animal models and in postmenopausal women.

Original languageEnglish (US)
Pages (from-to)390-395
Number of pages6
JournalAdvances in Chronic Kidney Disease
Volume20
Issue number5
DOIs
StatePublished - Sep 2013

Fingerprint

Kidney Diseases
Disease Progression
Estrogens
Kidney
Gonadal Steroid Hormones
Selective Estrogen Receptor Modulators
Diabetic Nephropathies
Transforming Growth Factors
Renin-Angiotensin System
Extracellular Matrix
Signal Transduction
Intercellular Signaling Peptides and Proteins
Theoretical Models
Animal Models
Hemodynamics
Cytokines
Wounds and Injuries
Genes

Keywords

  • CKD
  • Estrogen
  • Gender
  • Sex
  • Testosterone

ASJC Scopus subject areas

  • Nephrology

Cite this

Gender and the prevalence and progression of renal disease. / Neugarten, Joel; Golestaneh, Ladan.

In: Advances in Chronic Kidney Disease, Vol. 20, No. 5, 09.2013, p. 390-395.

Research output: Contribution to journalArticle

@article{256f219d651a4d1e84e320b7ccb80298,
title = "Gender and the prevalence and progression of renal disease",
abstract = "In most experimental models of CKD, male animals progress more rapidly than females. Modulation of the hormonal milieu can replicate the effects of gender on the course of kidney disease. These observations suggest that sex hormones per se may be important determinants of the greater susceptibility of males to progressive kidney injury. The predominance of data in humans suggests that the course of nondiabetic kidney disease is more aggressive in men than women. Male gender is arguably also a risk factor for progression of diabetic nephropathy. Sex hormones directly or indirectly affect many cellular processes by modulating the synthesis of various cytokines, growth factors, and vasoactive agents. In particular, estrogen acts in a receptor-dependent mechanism to regulate genes involved in extracellular matrix metabolism. Estrogen has profound effects on transforming growth factor-β signal transduction and on the renin-angiotensin system. These effects may contribute to alterations in kidney hemodynamics and affect kidney disease progression. Selective estrogen receptor modulators, agents that mimic many of the beneficial effects of estrogen without reproducing estrogen's deleterious effects on reproductive tissue, ameliorate the course of kidney disease in animal models and in postmenopausal women.",
keywords = "CKD, Estrogen, Gender, Sex, Testosterone",
author = "Joel Neugarten and Ladan Golestaneh",
year = "2013",
month = "9",
doi = "10.1053/j.ackd.2013.05.004",
language = "English (US)",
volume = "20",
pages = "390--395",
journal = "Advances in Chronic Kidney Disease",
issn = "1548-5595",
publisher = "W.B. Saunders Ltd",
number = "5",

}

TY - JOUR

T1 - Gender and the prevalence and progression of renal disease

AU - Neugarten, Joel

AU - Golestaneh, Ladan

PY - 2013/9

Y1 - 2013/9

N2 - In most experimental models of CKD, male animals progress more rapidly than females. Modulation of the hormonal milieu can replicate the effects of gender on the course of kidney disease. These observations suggest that sex hormones per se may be important determinants of the greater susceptibility of males to progressive kidney injury. The predominance of data in humans suggests that the course of nondiabetic kidney disease is more aggressive in men than women. Male gender is arguably also a risk factor for progression of diabetic nephropathy. Sex hormones directly or indirectly affect many cellular processes by modulating the synthesis of various cytokines, growth factors, and vasoactive agents. In particular, estrogen acts in a receptor-dependent mechanism to regulate genes involved in extracellular matrix metabolism. Estrogen has profound effects on transforming growth factor-β signal transduction and on the renin-angiotensin system. These effects may contribute to alterations in kidney hemodynamics and affect kidney disease progression. Selective estrogen receptor modulators, agents that mimic many of the beneficial effects of estrogen without reproducing estrogen's deleterious effects on reproductive tissue, ameliorate the course of kidney disease in animal models and in postmenopausal women.

AB - In most experimental models of CKD, male animals progress more rapidly than females. Modulation of the hormonal milieu can replicate the effects of gender on the course of kidney disease. These observations suggest that sex hormones per se may be important determinants of the greater susceptibility of males to progressive kidney injury. The predominance of data in humans suggests that the course of nondiabetic kidney disease is more aggressive in men than women. Male gender is arguably also a risk factor for progression of diabetic nephropathy. Sex hormones directly or indirectly affect many cellular processes by modulating the synthesis of various cytokines, growth factors, and vasoactive agents. In particular, estrogen acts in a receptor-dependent mechanism to regulate genes involved in extracellular matrix metabolism. Estrogen has profound effects on transforming growth factor-β signal transduction and on the renin-angiotensin system. These effects may contribute to alterations in kidney hemodynamics and affect kidney disease progression. Selective estrogen receptor modulators, agents that mimic many of the beneficial effects of estrogen without reproducing estrogen's deleterious effects on reproductive tissue, ameliorate the course of kidney disease in animal models and in postmenopausal women.

KW - CKD

KW - Estrogen

KW - Gender

KW - Sex

KW - Testosterone

UR - http://www.scopus.com/inward/record.url?scp=84882761422&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84882761422&partnerID=8YFLogxK

U2 - 10.1053/j.ackd.2013.05.004

DO - 10.1053/j.ackd.2013.05.004

M3 - Article

VL - 20

SP - 390

EP - 395

JO - Advances in Chronic Kidney Disease

JF - Advances in Chronic Kidney Disease

SN - 1548-5595

IS - 5

ER -