GBT440 increases haemoglobin oxygen affinity, reduces sickling and prolongs RBC half-life in a murine model of sickle cell disease

Donna Oksenberg, Kobina Dufu, Mira P. Patel, Chihyuan Chuang, Zhe Li, Qing Xu, Abel Silva-Garcia, Chengjing Zhou, Athiwat Hutchaleelaha, Larysa Patskovska, Yury Patskovsky, Steven C. Almo, Uma Sinha, Brian W. Metcalf, David R. Archer

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Medicine & Life Sciences