Gastrointestinal symptoms and motility disorders in patients with systemic scleroderma

Agostino Di Ciaula, Michele Covelli, Massimo Berardino, David Q.H. Wang, Giovanni Lapadula, Giuseppe Palasciano, Piero Portincasa

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Background: Studies on gastrointestinal symptoms, dysfunctions, and neurological disorders in systemic scleroderma are lacking so far. Methods: Thirty-eight scleroderma patients (34 limited, 4 diffuse), 60 healthy controls and 68 dyspeptic controls were scored for upper and lower gastrointestinal symptoms (dyspepsia, bowel habits), gastric and gallbladder emptying to liquid meal (functional ultrasonography) and small bowel transit (H2-breath test). Autonomic nerve function was assessed by cardiovascular tests. Results: The score for dyspepsia (mainly gastric fullness) was greater in scleroderma patients than healthy controls, but lower than dyspeptic controls who had multiple symptoms, instead. Scleroderma patients with dyspepsia had a longer disease duration. Fasting antral area and postprandial antral dilatation were smaller in scleroderma patients than dyspeptic and healthy controls. Gastric emptying was delayed in both scleroderma patients (particularly in those with abnormal dyspeptic score) and dyspeptic controls, who also showed a larger residual area. Despite gallbladder fasting and postprandial volumes were comparable across the three groups, gallbladder refilling appeared delayed in dyspeptic controls and mainly dependent on delayed gastric emptying in scleroderma. Small intestinal transit was also delayed in 74% of scleroderma and 66% of dyspeptic controls. Bowel habits were similar among the three groups. Autonomic neuropathy was not associated with dyspepsia, gastric and gallbladder motility and small intestinal transit. Conclusion: In scleroderma patients dyspepsia (mainly gastric fullness), restricted distension of the gastric antrum and diffuse gastrointestinal dysmotility are frequent features. These defects are independent from the occurrence of autonomic neuropathy.

Original languageEnglish (US)
Article number7
JournalBMC Gastroenterology
Volume8
DOIs
StatePublished - Apr 9 2008
Externally publishedYes

Fingerprint

Gastrointestinal Motility
Systemic Scleroderma
Dyspepsia
Gastric Emptying
Gallbladder
Stomach
Habits
Fasting
Gallbladder Emptying
Pyloric Antrum
Autonomic Pathways
Breath Tests
Nervous System Diseases
Meals
Dilatation
Ultrasonography

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Di Ciaula, A., Covelli, M., Berardino, M., Wang, D. Q. H., Lapadula, G., Palasciano, G., & Portincasa, P. (2008). Gastrointestinal symptoms and motility disorders in patients with systemic scleroderma. BMC Gastroenterology, 8, [7]. https://doi.org/10.1186/1471-230X-8-7

Gastrointestinal symptoms and motility disorders in patients with systemic scleroderma. / Di Ciaula, Agostino; Covelli, Michele; Berardino, Massimo; Wang, David Q.H.; Lapadula, Giovanni; Palasciano, Giuseppe; Portincasa, Piero.

In: BMC Gastroenterology, Vol. 8, 7, 09.04.2008.

Research output: Contribution to journalArticle

Di Ciaula, A, Covelli, M, Berardino, M, Wang, DQH, Lapadula, G, Palasciano, G & Portincasa, P 2008, 'Gastrointestinal symptoms and motility disorders in patients with systemic scleroderma', BMC Gastroenterology, vol. 8, 7. https://doi.org/10.1186/1471-230X-8-7
Di Ciaula, Agostino ; Covelli, Michele ; Berardino, Massimo ; Wang, David Q.H. ; Lapadula, Giovanni ; Palasciano, Giuseppe ; Portincasa, Piero. / Gastrointestinal symptoms and motility disorders in patients with systemic scleroderma. In: BMC Gastroenterology. 2008 ; Vol. 8.
@article{95aeaa23356042f18066fd0477eb536e,
title = "Gastrointestinal symptoms and motility disorders in patients with systemic scleroderma",
abstract = "Background: Studies on gastrointestinal symptoms, dysfunctions, and neurological disorders in systemic scleroderma are lacking so far. Methods: Thirty-eight scleroderma patients (34 limited, 4 diffuse), 60 healthy controls and 68 dyspeptic controls were scored for upper and lower gastrointestinal symptoms (dyspepsia, bowel habits), gastric and gallbladder emptying to liquid meal (functional ultrasonography) and small bowel transit (H2-breath test). Autonomic nerve function was assessed by cardiovascular tests. Results: The score for dyspepsia (mainly gastric fullness) was greater in scleroderma patients than healthy controls, but lower than dyspeptic controls who had multiple symptoms, instead. Scleroderma patients with dyspepsia had a longer disease duration. Fasting antral area and postprandial antral dilatation were smaller in scleroderma patients than dyspeptic and healthy controls. Gastric emptying was delayed in both scleroderma patients (particularly in those with abnormal dyspeptic score) and dyspeptic controls, who also showed a larger residual area. Despite gallbladder fasting and postprandial volumes were comparable across the three groups, gallbladder refilling appeared delayed in dyspeptic controls and mainly dependent on delayed gastric emptying in scleroderma. Small intestinal transit was also delayed in 74{\%} of scleroderma and 66{\%} of dyspeptic controls. Bowel habits were similar among the three groups. Autonomic neuropathy was not associated with dyspepsia, gastric and gallbladder motility and small intestinal transit. Conclusion: In scleroderma patients dyspepsia (mainly gastric fullness), restricted distension of the gastric antrum and diffuse gastrointestinal dysmotility are frequent features. These defects are independent from the occurrence of autonomic neuropathy.",
author = "{Di Ciaula}, Agostino and Michele Covelli and Massimo Berardino and Wang, {David Q.H.} and Giovanni Lapadula and Giuseppe Palasciano and Piero Portincasa",
year = "2008",
month = "4",
day = "9",
doi = "10.1186/1471-230X-8-7",
language = "English (US)",
volume = "8",
journal = "BMC Gastroenterology",
issn = "1471-230X",
publisher = "BioMed Central",

}

TY - JOUR

T1 - Gastrointestinal symptoms and motility disorders in patients with systemic scleroderma

AU - Di Ciaula, Agostino

AU - Covelli, Michele

AU - Berardino, Massimo

AU - Wang, David Q.H.

AU - Lapadula, Giovanni

AU - Palasciano, Giuseppe

AU - Portincasa, Piero

PY - 2008/4/9

Y1 - 2008/4/9

N2 - Background: Studies on gastrointestinal symptoms, dysfunctions, and neurological disorders in systemic scleroderma are lacking so far. Methods: Thirty-eight scleroderma patients (34 limited, 4 diffuse), 60 healthy controls and 68 dyspeptic controls were scored for upper and lower gastrointestinal symptoms (dyspepsia, bowel habits), gastric and gallbladder emptying to liquid meal (functional ultrasonography) and small bowel transit (H2-breath test). Autonomic nerve function was assessed by cardiovascular tests. Results: The score for dyspepsia (mainly gastric fullness) was greater in scleroderma patients than healthy controls, but lower than dyspeptic controls who had multiple symptoms, instead. Scleroderma patients with dyspepsia had a longer disease duration. Fasting antral area and postprandial antral dilatation were smaller in scleroderma patients than dyspeptic and healthy controls. Gastric emptying was delayed in both scleroderma patients (particularly in those with abnormal dyspeptic score) and dyspeptic controls, who also showed a larger residual area. Despite gallbladder fasting and postprandial volumes were comparable across the three groups, gallbladder refilling appeared delayed in dyspeptic controls and mainly dependent on delayed gastric emptying in scleroderma. Small intestinal transit was also delayed in 74% of scleroderma and 66% of dyspeptic controls. Bowel habits were similar among the three groups. Autonomic neuropathy was not associated with dyspepsia, gastric and gallbladder motility and small intestinal transit. Conclusion: In scleroderma patients dyspepsia (mainly gastric fullness), restricted distension of the gastric antrum and diffuse gastrointestinal dysmotility are frequent features. These defects are independent from the occurrence of autonomic neuropathy.

AB - Background: Studies on gastrointestinal symptoms, dysfunctions, and neurological disorders in systemic scleroderma are lacking so far. Methods: Thirty-eight scleroderma patients (34 limited, 4 diffuse), 60 healthy controls and 68 dyspeptic controls were scored for upper and lower gastrointestinal symptoms (dyspepsia, bowel habits), gastric and gallbladder emptying to liquid meal (functional ultrasonography) and small bowel transit (H2-breath test). Autonomic nerve function was assessed by cardiovascular tests. Results: The score for dyspepsia (mainly gastric fullness) was greater in scleroderma patients than healthy controls, but lower than dyspeptic controls who had multiple symptoms, instead. Scleroderma patients with dyspepsia had a longer disease duration. Fasting antral area and postprandial antral dilatation were smaller in scleroderma patients than dyspeptic and healthy controls. Gastric emptying was delayed in both scleroderma patients (particularly in those with abnormal dyspeptic score) and dyspeptic controls, who also showed a larger residual area. Despite gallbladder fasting and postprandial volumes were comparable across the three groups, gallbladder refilling appeared delayed in dyspeptic controls and mainly dependent on delayed gastric emptying in scleroderma. Small intestinal transit was also delayed in 74% of scleroderma and 66% of dyspeptic controls. Bowel habits were similar among the three groups. Autonomic neuropathy was not associated with dyspepsia, gastric and gallbladder motility and small intestinal transit. Conclusion: In scleroderma patients dyspepsia (mainly gastric fullness), restricted distension of the gastric antrum and diffuse gastrointestinal dysmotility are frequent features. These defects are independent from the occurrence of autonomic neuropathy.

UR - http://www.scopus.com/inward/record.url?scp=41549138305&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=41549138305&partnerID=8YFLogxK

U2 - 10.1186/1471-230X-8-7

DO - 10.1186/1471-230X-8-7

M3 - Article

C2 - 18304354

AN - SCOPUS:41549138305

VL - 8

JO - BMC Gastroenterology

JF - BMC Gastroenterology

SN - 1471-230X

M1 - 7

ER -