Abstract
Conclusion. Gastrointestinal hormones and their antagonists can alter the growth of pancreatic adenocarcinoma in vitro and in vivo. The potential clinical benefit of this approach deserves further study. Background. Epithelial cell growth is normally under hormonal control. Hormones also affect the growth of many epithelial cancers, and this fact is used to modify tumor growth. Pancreatic epithelial cell growth is under the influence of gastrointestinal hormones. This article reviews experiments designed to determine the effect of gastrointestinal hormones on the growth of pancreatic adenocarcinoma. Methods. Eighty-eight articles were identified from a Medline search using the terms pancreatic adenocarcinoma and the individual names of gastrointestinal hormones. The experimental design and results of these studies are reviewed. Results. In general, somatostatin, vasoactive intestinal polypeptide, pancreatic polypeptide, and pancreastatin inhibit pancreatic adenocarcinoma growth. Cholecystokinin, secretin, bombesin, gastrin, EGF, TGF-α, insulin, and IGF-1 have a growth-promoting effect.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 169-180 |
| Number of pages | 12 |
| Journal | International Journal of Pancreatology |
| Volume | 24 |
| Issue number | 3 |
| State | Published - 1998 |
| Externally published | Yes |
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Keywords
- Gastrointestinal hormones
- Pancreatic adenocarcinoma
ASJC Scopus subject areas
- Oncology
- Endocrinology
- Gastroenterology
Cite this
Gastrointestinal hormones as potential adjuvant treatment of exocrine pancreatic adenocarcinoma. / Fisher, William E.; Muscarella, Peter; Boros, Laszlo G.; Schirmer, William J.
In: International Journal of Pancreatology, Vol. 24, No. 3, 1998, p. 169-180.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Gastrointestinal hormones as potential adjuvant treatment of exocrine pancreatic adenocarcinoma
AU - Fisher, William E.
AU - Muscarella, Peter
AU - Boros, Laszlo G.
AU - Schirmer, William J.
PY - 1998
Y1 - 1998
N2 - Conclusion. Gastrointestinal hormones and their antagonists can alter the growth of pancreatic adenocarcinoma in vitro and in vivo. The potential clinical benefit of this approach deserves further study. Background. Epithelial cell growth is normally under hormonal control. Hormones also affect the growth of many epithelial cancers, and this fact is used to modify tumor growth. Pancreatic epithelial cell growth is under the influence of gastrointestinal hormones. This article reviews experiments designed to determine the effect of gastrointestinal hormones on the growth of pancreatic adenocarcinoma. Methods. Eighty-eight articles were identified from a Medline search using the terms pancreatic adenocarcinoma and the individual names of gastrointestinal hormones. The experimental design and results of these studies are reviewed. Results. In general, somatostatin, vasoactive intestinal polypeptide, pancreatic polypeptide, and pancreastatin inhibit pancreatic adenocarcinoma growth. Cholecystokinin, secretin, bombesin, gastrin, EGF, TGF-α, insulin, and IGF-1 have a growth-promoting effect.
AB - Conclusion. Gastrointestinal hormones and their antagonists can alter the growth of pancreatic adenocarcinoma in vitro and in vivo. The potential clinical benefit of this approach deserves further study. Background. Epithelial cell growth is normally under hormonal control. Hormones also affect the growth of many epithelial cancers, and this fact is used to modify tumor growth. Pancreatic epithelial cell growth is under the influence of gastrointestinal hormones. This article reviews experiments designed to determine the effect of gastrointestinal hormones on the growth of pancreatic adenocarcinoma. Methods. Eighty-eight articles were identified from a Medline search using the terms pancreatic adenocarcinoma and the individual names of gastrointestinal hormones. The experimental design and results of these studies are reviewed. Results. In general, somatostatin, vasoactive intestinal polypeptide, pancreatic polypeptide, and pancreastatin inhibit pancreatic adenocarcinoma growth. Cholecystokinin, secretin, bombesin, gastrin, EGF, TGF-α, insulin, and IGF-1 have a growth-promoting effect.
KW - Gastrointestinal hormones
KW - Pancreatic adenocarcinoma
UR - http://www.scopus.com/inward/record.url?scp=0032408106&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0032408106&partnerID=8YFLogxK
M3 - Review article
VL - 24
SP - 169
EP - 180
JO - Journal of Gastrointestinal Cancer
JF - Journal of Gastrointestinal Cancer
SN - 1941-6628
IS - 3
ER -