Gastrointestinal Bleeding During Continuous-Flow Left Ventricular Assist Device Support

State of the Field

Rachna Kataria, Ulrich P. Jorde

Research output: Contribution to journalReview article

2 Citations (Scopus)

Abstract

Continuous-flow left ventricular assist devices (CF-LVADs) are increasingly used for the management of advanced heart failure refractory to optimal medical therapy. Despite the encouraging outcomes with CF-LVADs, gastrointestinal bleeding (GIB) continues to be a rather concerning complication resulting in increased rates of readmission and increased morbidity. The exact pathophysiology of CF-LVAD-associated GIB remains poorly understood, and this lack of knowledge limits our ability to control this morbid complication. What is clear, however, is that the majority of GIB episodes in LVAD patients are due to fragile GI arteriovenous malformations or angiodysplasias, in the setting of CF-LVAD-associated acquired von Willebrand syndrome. We will, herein, appraise the proposed interactions between different pathophysiological processes thought to be causing angiodysplasias and GIB in patients on CF-LVAD support.

Original languageEnglish (US)
Pages (from-to)8-13
Number of pages6
JournalCardiology in review
Volume27
Issue number1
DOIs
StatePublished - Jan 1 2019

Fingerprint

Heart-Assist Devices
Hemorrhage
Angiodysplasia
Arteriovenous Malformations
Heart Failure
Morbidity

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Gastrointestinal Bleeding During Continuous-Flow Left Ventricular Assist Device Support : State of the Field. / Kataria, Rachna; Jorde, Ulrich P.

In: Cardiology in review, Vol. 27, No. 1, 01.01.2019, p. 8-13.

Research output: Contribution to journalReview article

@article{83787e69cd2a461da167f8c54c84afbb,
title = "Gastrointestinal Bleeding During Continuous-Flow Left Ventricular Assist Device Support: State of the Field",
abstract = "Continuous-flow left ventricular assist devices (CF-LVADs) are increasingly used for the management of advanced heart failure refractory to optimal medical therapy. Despite the encouraging outcomes with CF-LVADs, gastrointestinal bleeding (GIB) continues to be a rather concerning complication resulting in increased rates of readmission and increased morbidity. The exact pathophysiology of CF-LVAD-associated GIB remains poorly understood, and this lack of knowledge limits our ability to control this morbid complication. What is clear, however, is that the majority of GIB episodes in LVAD patients are due to fragile GI arteriovenous malformations or angiodysplasias, in the setting of CF-LVAD-associated acquired von Willebrand syndrome. We will, herein, appraise the proposed interactions between different pathophysiological processes thought to be causing angiodysplasias and GIB in patients on CF-LVAD support.",
author = "Rachna Kataria and Jorde, {Ulrich P.}",
year = "2019",
month = "1",
day = "1",
doi = "10.1097/CRD.0000000000000212",
language = "English (US)",
volume = "27",
pages = "8--13",
journal = "Cardiology in Review",
issn = "1061-5377",
publisher = "Lippincott Williams and Wilkins",
number = "1",

}

TY - JOUR

T1 - Gastrointestinal Bleeding During Continuous-Flow Left Ventricular Assist Device Support

T2 - State of the Field

AU - Kataria, Rachna

AU - Jorde, Ulrich P.

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Continuous-flow left ventricular assist devices (CF-LVADs) are increasingly used for the management of advanced heart failure refractory to optimal medical therapy. Despite the encouraging outcomes with CF-LVADs, gastrointestinal bleeding (GIB) continues to be a rather concerning complication resulting in increased rates of readmission and increased morbidity. The exact pathophysiology of CF-LVAD-associated GIB remains poorly understood, and this lack of knowledge limits our ability to control this morbid complication. What is clear, however, is that the majority of GIB episodes in LVAD patients are due to fragile GI arteriovenous malformations or angiodysplasias, in the setting of CF-LVAD-associated acquired von Willebrand syndrome. We will, herein, appraise the proposed interactions between different pathophysiological processes thought to be causing angiodysplasias and GIB in patients on CF-LVAD support.

AB - Continuous-flow left ventricular assist devices (CF-LVADs) are increasingly used for the management of advanced heart failure refractory to optimal medical therapy. Despite the encouraging outcomes with CF-LVADs, gastrointestinal bleeding (GIB) continues to be a rather concerning complication resulting in increased rates of readmission and increased morbidity. The exact pathophysiology of CF-LVAD-associated GIB remains poorly understood, and this lack of knowledge limits our ability to control this morbid complication. What is clear, however, is that the majority of GIB episodes in LVAD patients are due to fragile GI arteriovenous malformations or angiodysplasias, in the setting of CF-LVAD-associated acquired von Willebrand syndrome. We will, herein, appraise the proposed interactions between different pathophysiological processes thought to be causing angiodysplasias and GIB in patients on CF-LVAD support.

UR - http://www.scopus.com/inward/record.url?scp=85062890233&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85062890233&partnerID=8YFLogxK

U2 - 10.1097/CRD.0000000000000212

DO - 10.1097/CRD.0000000000000212

M3 - Review article

VL - 27

SP - 8

EP - 13

JO - Cardiology in Review

JF - Cardiology in Review

SN - 1061-5377

IS - 1

ER -