Gastrointestinal bleeding during continuous-flow left ventricular assist device support state of the field

Rachna Kataria, Ulrich P. Jorde

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Continuous-flow left ventricular assist devices (CF-LVADs) are increasingly used for the management of advanced heart failure refractory to optimal medical therapy. Despite the encouraging outcomes with CF-LVADs, gastrointestinal bleeding (GIB) continues to be a rather concerning complication resulting in increased rates of readmission and increased morbidity. The exact pathophysiology of CF-LVAD-associated GIB remains poorly understood, and this lack of knowledge limits our ability to control this morbid complication. What is clear, however, is that the majority of GIB episodes in LVAD patients are due to fragile GI arteriovenous malformations or angiodysplasias, in the setting of CF-LVAD-associated acquired von Willebrand syndrome. We will, herein, appraise the proposed interactions between different pathophysiological processes thought to be causing angiodysplasias and GIB in patients on CF-LVAD support.

Original languageEnglish (US)
Pages (from-to)8-13
Number of pages6
JournalCardiology in review
Volume27
Issue number1
DOIs
StatePublished - Jan 1 2019

Keywords

  • Angiodysplasia
  • Angiopoietin-2
  • Continuous-flow left ventricular assist device
  • Gastrointestinal bleeding
  • Von Willebrand factor

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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