Abstract
Continuous-flow left ventricular assist devices (CF-LVADs) are increasingly used for the management of advanced heart failure refractory to optimal medical therapy. Despite the encouraging outcomes with CF-LVADs, gastrointestinal bleeding (GIB) continues to be a rather concerning complication resulting in increased rates of readmission and increased morbidity. The exact pathophysiology of CF-LVAD-associated GIB remains poorly understood, and this lack of knowledge limits our ability to control this morbid complication. What is clear, however, is that the majority of GIB episodes in LVAD patients are due to fragile GI arteriovenous malformations or angiodysplasias, in the setting of CF-LVAD-associated acquired von Willebrand syndrome. We will, herein, appraise the proposed interactions between different pathophysiological processes thought to be causing angiodysplasias and GIB in patients on CF-LVAD support.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 8-13 |
| Number of pages | 6 |
| Journal | Cardiology in review |
| Volume | 27 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 1 2019 |
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ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
Cite this
Gastrointestinal Bleeding During Continuous-Flow Left Ventricular Assist Device Support : State of the Field. / Kataria, Rachna; Jorde, Ulrich P.
In: Cardiology in review, Vol. 27, No. 1, 01.01.2019, p. 8-13.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Gastrointestinal Bleeding During Continuous-Flow Left Ventricular Assist Device Support
T2 - State of the Field
AU - Kataria, Rachna
AU - Jorde, Ulrich P.
PY - 2019/1/1
Y1 - 2019/1/1
N2 - Continuous-flow left ventricular assist devices (CF-LVADs) are increasingly used for the management of advanced heart failure refractory to optimal medical therapy. Despite the encouraging outcomes with CF-LVADs, gastrointestinal bleeding (GIB) continues to be a rather concerning complication resulting in increased rates of readmission and increased morbidity. The exact pathophysiology of CF-LVAD-associated GIB remains poorly understood, and this lack of knowledge limits our ability to control this morbid complication. What is clear, however, is that the majority of GIB episodes in LVAD patients are due to fragile GI arteriovenous malformations or angiodysplasias, in the setting of CF-LVAD-associated acquired von Willebrand syndrome. We will, herein, appraise the proposed interactions between different pathophysiological processes thought to be causing angiodysplasias and GIB in patients on CF-LVAD support.
AB - Continuous-flow left ventricular assist devices (CF-LVADs) are increasingly used for the management of advanced heart failure refractory to optimal medical therapy. Despite the encouraging outcomes with CF-LVADs, gastrointestinal bleeding (GIB) continues to be a rather concerning complication resulting in increased rates of readmission and increased morbidity. The exact pathophysiology of CF-LVAD-associated GIB remains poorly understood, and this lack of knowledge limits our ability to control this morbid complication. What is clear, however, is that the majority of GIB episodes in LVAD patients are due to fragile GI arteriovenous malformations or angiodysplasias, in the setting of CF-LVAD-associated acquired von Willebrand syndrome. We will, herein, appraise the proposed interactions between different pathophysiological processes thought to be causing angiodysplasias and GIB in patients on CF-LVAD support.
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UR - http://www.scopus.com/inward/citedby.url?scp=85062890233&partnerID=8YFLogxK
U2 - 10.1097/CRD.0000000000000212
DO - 10.1097/CRD.0000000000000212
M3 - Review article
C2 - 30520778
AN - SCOPUS:85062890233
VL - 27
SP - 8
EP - 13
JO - Cardiology in Review
JF - Cardiology in Review
SN - 1061-5377
IS - 1
ER -