TY - JOUR
T1 - Gastrointestinal bleeding during continuous-flow left ventricular assist device support state of the field
AU - Kataria, Rachna
AU - Jorde, Ulrich P.
N1 - Publisher Copyright:
© 2018 Wolters Kluwer Health, Inc.
PY - 2019
Y1 - 2019
N2 - Continuous-flow left ventricular assist devices (CF-LVADs) are increasingly used for the management of advanced heart failure refractory to optimal medical therapy. Despite the encouraging outcomes with CF-LVADs, gastrointestinal bleeding (GIB) continues to be a rather concerning complication resulting in increased rates of readmission and increased morbidity. The exact pathophysiology of CF-LVAD-associated GIB remains poorly understood, and this lack of knowledge limits our ability to control this morbid complication. What is clear, however, is that the majority of GIB episodes in LVAD patients are due to fragile GI arteriovenous malformations or angiodysplasias, in the setting of CF-LVAD-associated acquired von Willebrand syndrome. We will, herein, appraise the proposed interactions between different pathophysiological processes thought to be causing angiodysplasias and GIB in patients on CF-LVAD support.
AB - Continuous-flow left ventricular assist devices (CF-LVADs) are increasingly used for the management of advanced heart failure refractory to optimal medical therapy. Despite the encouraging outcomes with CF-LVADs, gastrointestinal bleeding (GIB) continues to be a rather concerning complication resulting in increased rates of readmission and increased morbidity. The exact pathophysiology of CF-LVAD-associated GIB remains poorly understood, and this lack of knowledge limits our ability to control this morbid complication. What is clear, however, is that the majority of GIB episodes in LVAD patients are due to fragile GI arteriovenous malformations or angiodysplasias, in the setting of CF-LVAD-associated acquired von Willebrand syndrome. We will, herein, appraise the proposed interactions between different pathophysiological processes thought to be causing angiodysplasias and GIB in patients on CF-LVAD support.
KW - Angiodysplasia
KW - Angiopoietin-2
KW - Continuous-flow left ventricular assist device
KW - Gastrointestinal bleeding
KW - Von Willebrand factor
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U2 - 10.1097/CRD.0000000000000212
DO - 10.1097/CRD.0000000000000212
M3 - Article
C2 - 30520778
AN - SCOPUS:85062890233
SN - 1061-5377
VL - 27
SP - 8
EP - 13
JO - Cardiology in Review
JF - Cardiology in Review
IS - 1
ER -