Gastroesophageal reflux associated with nemaline myopathy of infancy

S. Berezin, L. J. Newman, S. M. Schwarz, A. J. Spiro

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

A severe infantile form of nemaline myopathy has a high mortality rate when untreated because of subsequent malnutrition and respiratory failure. Three infants with this condition demonstrated persistent vomiting, poor weight gain, and recurrent pneumonias. Esophageal manometry demonstrated decreased lower esophageal sphincter pressures and low amplitude peristalsis; 24-hour esophageal pH monitoring revealed significant gastroesophageal reflux. Medical therapy was ineffective in relieving symptoms. After antireflux surgery, vomiting and respiratory symptoms ceased, and there was no longer significant gastroesophageal reflux during pH monitoring. Our experience indicates that in some infants with nemaline myopathy a severe form of gastroesophageal reflux develops that is not responsive to medical therapy. Early surgical intervention may decrease life-threatening complications associated with gastroesophageal reflux in these infants.

Original languageEnglish (US)
Pages (from-to)111-115
Number of pages5
JournalPediatrics
Volume81
Issue number1
StatePublished - 1988
Externally publishedYes

Fingerprint

Nemaline Myopathies
Gastroesophageal Reflux
Vomiting
Esophageal pH Monitoring
Peristalsis
Lower Esophageal Sphincter
Manometry
Malnutrition
Respiratory Insufficiency
Weight Gain
Pneumonia
Pressure
Mortality
Therapeutics

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Berezin, S., Newman, L. J., Schwarz, S. M., & Spiro, A. J. (1988). Gastroesophageal reflux associated with nemaline myopathy of infancy. Pediatrics, 81(1), 111-115.

Gastroesophageal reflux associated with nemaline myopathy of infancy. / Berezin, S.; Newman, L. J.; Schwarz, S. M.; Spiro, A. J.

In: Pediatrics, Vol. 81, No. 1, 1988, p. 111-115.

Research output: Contribution to journalArticle

Berezin, S, Newman, LJ, Schwarz, SM & Spiro, AJ 1988, 'Gastroesophageal reflux associated with nemaline myopathy of infancy', Pediatrics, vol. 81, no. 1, pp. 111-115.
Berezin S, Newman LJ, Schwarz SM, Spiro AJ. Gastroesophageal reflux associated with nemaline myopathy of infancy. Pediatrics. 1988;81(1):111-115.
Berezin, S. ; Newman, L. J. ; Schwarz, S. M. ; Spiro, A. J. / Gastroesophageal reflux associated with nemaline myopathy of infancy. In: Pediatrics. 1988 ; Vol. 81, No. 1. pp. 111-115.
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