Gastric and duodenal features of meals mediate controls of liquid gastric emptying during fill in rhesus monkeys

Timothy H. Moran, Susan Knipp, Gary J. Schwartz

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

To study the dynamics of liquid gastric emptying in rhesus monkeys under conditions that simulated gastric fill during a meal, we measured the gastric emptying of liquid glucose at various concentrations and volumes when administered intragastrically at rates ranging from 12.5 to 37.5 ml/min. Glucose gastric emptying was faster during than following the period of gastric fill. At a single glucose concentration, volume infused rather than the rate of filling determined the volume emptied. Lower glucose concentrations emptied more slowly than physiological saline. As glucose concentration increased, emptying during fill slowed. Duodenal glucose infusions greatly slowed the rate of saline emptying during fill, demonstrating duodenal feedback control. Although casein hydrolosate emptied more rapidly than glucose, the dynamics of volume and concentration dependency and the role of duodenal feedback were similar. These data reveal that both gastric volume and duodenal negative feedback controls important in gastric emptying following stomach filling also contribute to its control during fill.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology
Volume277
Issue number5 46-5
StatePublished - Nov 1999
Externally publishedYes

Fingerprint

Gastric Emptying
Macaca mulatta
Meals
Stomach
Glucose
Caseins

Keywords

  • Casein hydrolosate
  • Duodenal feedback
  • Glucose

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

Cite this

@article{a70c437d459945a5a306567d160e25b1,
title = "Gastric and duodenal features of meals mediate controls of liquid gastric emptying during fill in rhesus monkeys",
abstract = "To study the dynamics of liquid gastric emptying in rhesus monkeys under conditions that simulated gastric fill during a meal, we measured the gastric emptying of liquid glucose at various concentrations and volumes when administered intragastrically at rates ranging from 12.5 to 37.5 ml/min. Glucose gastric emptying was faster during than following the period of gastric fill. At a single glucose concentration, volume infused rather than the rate of filling determined the volume emptied. Lower glucose concentrations emptied more slowly than physiological saline. As glucose concentration increased, emptying during fill slowed. Duodenal glucose infusions greatly slowed the rate of saline emptying during fill, demonstrating duodenal feedback control. Although casein hydrolosate emptied more rapidly than glucose, the dynamics of volume and concentration dependency and the role of duodenal feedback were similar. These data reveal that both gastric volume and duodenal negative feedback controls important in gastric emptying following stomach filling also contribute to its control during fill.",
keywords = "Casein hydrolosate, Duodenal feedback, Glucose",
author = "Moran, {Timothy H.} and Susan Knipp and Schwartz, {Gary J.}",
year = "1999",
month = "11",
language = "English (US)",
volume = "277",
journal = "American Journal of Physiology - Renal Fluid and Electrolyte Physiology",
issn = "1931-857X",
publisher = "American Physiological Society",
number = "5 46-5",

}

TY - JOUR

T1 - Gastric and duodenal features of meals mediate controls of liquid gastric emptying during fill in rhesus monkeys

AU - Moran, Timothy H.

AU - Knipp, Susan

AU - Schwartz, Gary J.

PY - 1999/11

Y1 - 1999/11

N2 - To study the dynamics of liquid gastric emptying in rhesus monkeys under conditions that simulated gastric fill during a meal, we measured the gastric emptying of liquid glucose at various concentrations and volumes when administered intragastrically at rates ranging from 12.5 to 37.5 ml/min. Glucose gastric emptying was faster during than following the period of gastric fill. At a single glucose concentration, volume infused rather than the rate of filling determined the volume emptied. Lower glucose concentrations emptied more slowly than physiological saline. As glucose concentration increased, emptying during fill slowed. Duodenal glucose infusions greatly slowed the rate of saline emptying during fill, demonstrating duodenal feedback control. Although casein hydrolosate emptied more rapidly than glucose, the dynamics of volume and concentration dependency and the role of duodenal feedback were similar. These data reveal that both gastric volume and duodenal negative feedback controls important in gastric emptying following stomach filling also contribute to its control during fill.

AB - To study the dynamics of liquid gastric emptying in rhesus monkeys under conditions that simulated gastric fill during a meal, we measured the gastric emptying of liquid glucose at various concentrations and volumes when administered intragastrically at rates ranging from 12.5 to 37.5 ml/min. Glucose gastric emptying was faster during than following the period of gastric fill. At a single glucose concentration, volume infused rather than the rate of filling determined the volume emptied. Lower glucose concentrations emptied more slowly than physiological saline. As glucose concentration increased, emptying during fill slowed. Duodenal glucose infusions greatly slowed the rate of saline emptying during fill, demonstrating duodenal feedback control. Although casein hydrolosate emptied more rapidly than glucose, the dynamics of volume and concentration dependency and the role of duodenal feedback were similar. These data reveal that both gastric volume and duodenal negative feedback controls important in gastric emptying following stomach filling also contribute to its control during fill.

KW - Casein hydrolosate

KW - Duodenal feedback

KW - Glucose

UR - http://www.scopus.com/inward/record.url?scp=0032762305&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032762305&partnerID=8YFLogxK

M3 - Article

C2 - 10564198

AN - SCOPUS:0032762305

VL - 277

JO - American Journal of Physiology - Renal Fluid and Electrolyte Physiology

JF - American Journal of Physiology - Renal Fluid and Electrolyte Physiology

SN - 1931-857X

IS - 5 46-5

ER -