Gap junctions as electrical synapses

Juan Mauricio Garré, Michael V. L. Bennett

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Citations (Scopus)

Abstract

Gap junctions form between many cell types. Between neurons, they constitute one class of electrical synapses. Gap junctions are aggregates of membrane channels between the conjoined cells and in mammals they are comprised of connexins, which are encoded by a gene family that has 21 members in humans. Each of the coupled cells contributes a hemichannel to each cell-cell channel. Channel turnover can occur within hours, or channels may last a lifetime. Not all connexins will form channels with every other connexin, and connexin compatibility is one limit on junction formation. Other mechanisms including cell attachment and recognition molecules contribute to specificity of gap junction formation. Electrical synapses are characterized by specificity, but mistakes, i.e., inappropriate connections, are sometimes made. Pannexins/innexins form gap junctions in invertebrates, but apparently only hemichannels in mammals.

Original languageEnglish (US)
Title of host publicationThe Sticky Synapse: Cell Adhesion Molecules and Their Role in Synapse Formation and Maintenance
PublisherSpringer New York
Pages423-439
Number of pages17
ISBN (Print)9780387927084, 9780387927077
DOIs
StatePublished - 2009

Fingerprint

Electrical Synapses
Gap Junctions
Connexins
Mammals
Invertebrates
Ion Channels
Neurons
Genes

Keywords

  • Connexin
  • Dye coupling
  • Electrical coupling
  • Gap junction
  • Innexin
  • Pannexin
  • Synaptic delay
  • Synchronization

ASJC Scopus subject areas

  • Medicine(all)
  • Neuroscience(all)

Cite this

Garré, J. M., & Bennett, M. V. L. (2009). Gap junctions as electrical synapses. In The Sticky Synapse: Cell Adhesion Molecules and Their Role in Synapse Formation and Maintenance (pp. 423-439). Springer New York. https://doi.org/10.1007/978-0-387-92708-4_21

Gap junctions as electrical synapses. / Garré, Juan Mauricio; Bennett, Michael V. L.

The Sticky Synapse: Cell Adhesion Molecules and Their Role in Synapse Formation and Maintenance. Springer New York, 2009. p. 423-439.

Research output: Chapter in Book/Report/Conference proceedingChapter

Garré, JM & Bennett, MVL 2009, Gap junctions as electrical synapses. in The Sticky Synapse: Cell Adhesion Molecules and Their Role in Synapse Formation and Maintenance. Springer New York, pp. 423-439. https://doi.org/10.1007/978-0-387-92708-4_21
Garré JM, Bennett MVL. Gap junctions as electrical synapses. In The Sticky Synapse: Cell Adhesion Molecules and Their Role in Synapse Formation and Maintenance. Springer New York. 2009. p. 423-439 https://doi.org/10.1007/978-0-387-92708-4_21
Garré, Juan Mauricio ; Bennett, Michael V. L. / Gap junctions as electrical synapses. The Sticky Synapse: Cell Adhesion Molecules and Their Role in Synapse Formation and Maintenance. Springer New York, 2009. pp. 423-439
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