Gap junctions and Bystander effects: Good Samaritans and executioners

David C. Spray, Regina Hanstein, Sandra V. Lopez-Quintero, Randy F. Stout, Sylvia O. Suadicani, Mia M. Thi

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

The 'Bystander' and 'Good Samaritan' effects involve the transfer of toxic or beneficial compounds from one cell to a generally adjacent other through gap junction channels and through extracellular routes. The variety of injuries in which bystander cell killing or protection occurs has greatly expanded in the last decade to include infectious agents and therapeutic compounds, radiation injury, chaperones in cell therapy and apoptosis in development. This has been accompanied by the appreciation that both gap junction mediated and paracrine routes are used for the signaling of the 'kiss of life' and the 'kiss of death' and that manipulations of these pathways and the molecules that use them may find therapeutic utility in treatment of a variety of pathological conditions.

Original languageEnglish (US)
Pages (from-to)1-15
Number of pages15
JournalWiley Interdisciplinary Reviews: Membrane Transport and Signaling
Volume2
Issue number1
DOIs
StatePublished - Jan 2013

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Bystander Effect
Gap Junctions
Radiation Injuries
Poisons
Cell- and Tissue-Based Therapy
Therapeutics
Apoptosis
Wounds and Injuries

ASJC Scopus subject areas

  • Biophysics
  • Cellular and Molecular Neuroscience

Cite this

Gap junctions and Bystander effects : Good Samaritans and executioners. / Spray, David C.; Hanstein, Regina; Lopez-Quintero, Sandra V.; Stout, Randy F.; Suadicani, Sylvia O.; Thi, Mia M.

In: Wiley Interdisciplinary Reviews: Membrane Transport and Signaling, Vol. 2, No. 1, 01.2013, p. 1-15.

Research output: Contribution to journalArticle

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