Gap junctional conductance: Comparison of sensitivities to H and Ca ions

D. C. Spray, J. H. Stern, A. L. Harris, M. V.L. Bennett

Research output: Contribution to journalArticle

120 Scopus citations

Abstract

One cytoplasmic aspect of the junctional membrane between coupled pairs of Fundulus blastomeres was perfused with solutions of known H and Ca ion concentrations. Conductance of junctional membrane was decreased by either ion. The sensitivity to H ions was about 10,000 times greater than that to Ca ions. The results suggest that junctional conductance can be modulated by changes in H ion concentration near physiological pH, but that unphysiologically high concentrations of Ca ion, such as would be reached only on cell death, are required for comparable changes in junctional conductance.

Original languageEnglish (US)
Pages (from-to)441-445
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume79
Issue number2 I
DOIs
StatePublished - 1982

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