Galectins CLIC cargo inside

Research output: Contribution to journalReview articlepeer-review

7 Scopus citations


Clathrin-independent endocytosis removes membrane receptors and other proteins from the cell surface, yet the mechanisms controlling this process remain unclear. Galectin-3 is now shown to regulate the biogenesis of a subpopulation of clathrin-independent carriers (CLICs). Galectin-3 binds to glycosylated cargo proteins and interacts with membrane glycosphingolipids to induce membrane deformation and CLIC formation.

Original languageEnglish (US)
Pages (from-to)506-507
Number of pages2
JournalNature Cell Biology
Issue number6
StatePublished - Jun 2014

ASJC Scopus subject areas

  • Cell Biology

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