Gadolinium-based contrast agents — review of recent literature on magnetic resonance imaging signal intensity changes and tissue deposits, with emphasis on pediatric patients

Einat Blumfield, David W. Swenson, Ramesh S. Iyer, A. Luana Stanescu

Research output: Contribution to journalReview article

11 Scopus citations

Abstract

Gadolinium has been used as a base for contrast agents in MRI for the last three decades. Numerous studies over the last 4 years have reported increased signal intensity in deep brain nuclei in non-contrast MRI images following gadolinium-based contrast agent (GBCA) administration. Pathology studies performed on adults and children, and rodent necropsy studies have also shown gadolinium deposition in brain and other tissues after GBCA administration. The purpose of this review was to summarize and discuss the knowledge gained from these reports and the relevance for imaging pediatric patients.

Original languageEnglish (US)
Pages (from-to)448-457
Number of pages10
JournalPediatric radiology
Volume49
Issue number4
DOIs
StatePublished - Apr 1 2019

Keywords

  • Brain
  • Children
  • Deposition
  • Gadolinium
  • Gadolinium-based contrast agents
  • Magnetic resonance imaging
  • T1 signal

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Radiology Nuclear Medicine and imaging

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