Abstract
The p38 and JNK stress-activated MAPK signal transduction pathways are activated by T cell receptor (TCR) signaling and are required for IFN-γ production by TH1 effector cells. Here, we show that the expression of GADD45γ is induced during T cell activation and that the level of expression is higher in TH1 cells than in TH2 cells. TH1 cells from GADD45γ-/- mice are severely compromised in their abilities to activate p38 and JNK in response to TCR signaling, produce much less IFN-γ upon restimulation, and are deficient in activation-induced cell death (AICD). Additionally, GADD45γ deficiencies caused reduced contact hypersensitivity in mice. Thus, GADD45γ mediates activation of the p38 and JNK pathways and effector function of TH1 cells.
Original language | English (US) |
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Article number | 139 |
Pages (from-to) | 583-590 |
Number of pages | 8 |
Journal | Immunity |
Volume | 14 |
Issue number | 5 |
DOIs | |
State | Published - 2001 |
Externally published | Yes |
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology
- Infectious Diseases