GABAA receptors in normal development and seizures: Friends or foes?

Research output: Contribution to journalArticle

65 Citations (Scopus)

Abstract

GABAA receptors have an age-adapted function in the brain. During early development, they mediate excitatory effects resulting in activation of calcium sensitive signaling processes that are important for the differentiation of the brain. In more mature stages of development and in adults, GABAA receptors transmit inhibitory signals. The maturation of GABAA signaling follows sex-specific patterns, which appear to also be important for the sexual differentiation of the brain. The inhibitory effects of GABAA receptor activation have been widely exploited in the treatment of conditions where neuronal silencing is necessary. For instance, drugs that target GABAA receptors are the mainstay of treatment of seizures. Rccent evidence suggests however that the physiology and function of GABAA receptors changes in the brain of a subject that has epilepsy or status epilepticus. This review will summarize the physiology of and the developmental factors regulating the signaling and function of GABAA receptors; how these may change in the brain that has experienced prior seizures; what are the implications for the age and sex specific treatment of seizures and status epilepticus. Finally, the implications of these changes for the treatment of certain forms of medically refractory epilepsies and status epilepticus will be discussed.

Original languageEnglish (US)
Pages (from-to)1-20
Number of pages20
JournalCurrent Neuropharmacology
Volume6
Issue number1
DOIs
StatePublished - Mar 2008

Fingerprint

GABA-A Receptors
Seizures
Status Epilepticus
Brain
Epilepsy
Sex Differentiation
Calcium Signaling
Therapeutics
Pharmaceutical Preparations

Keywords

  • Brain
  • Chloride
  • Development
  • Expression
  • GABA
  • Hippocampus
  • Physiology
  • Seizure

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology
  • Pharmacology
  • Psychiatry and Mental health

Cite this

GABAA receptors in normal development and seizures : Friends or foes? / Galanopoulou, Aristea S.

In: Current Neuropharmacology, Vol. 6, No. 1, 03.2008, p. 1-20.

Research output: Contribution to journalArticle

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