GABA receptors, progesterone and premenstrual dysphoric disorder

Inger Sundström Poromaa, S. Smith, M. Gulinello

Research output: Contribution to journalArticle

92 Scopus citations

Abstract

Premenstrual dysphoric disorder (PMDD) is characterized by depression, anxiety and other affective symptoms which recur in the luteal phase of the menstrual cycle. Evidence from animal models of depression and anxiety indicate the importance of neuroactive steroid hormones and the GABAA receptor in the etiology and potential treatment of mood disorders. These data are reviewed in the light of human clinical studies and specific animal models of PMDD.

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Keywords

  • Allopregnanolone
  • Animal model
  • Anxiety
  • Benzodiazepine
  • Depression
  • GABA
  • GABAR subunit
  • Human
  • Mood
  • Neurosteroid
  • Premenstrual dysphoric disorder PMDD
  • Progesterone
  • Stress

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Psychiatry and Mental health

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