TY - JOUR
T1 - G protein-coupled receptor kinases and hypertension
T2 - A review of disease mechanisms
AU - Iaccarino, Guido
AU - Campanile, Alfonso
AU - Santulli, Gaetano
AU - Zuppieri, Francesco
AU - Koch, Walter J.
N1 - Funding Information:
Guido Iaccarino is supported by MIUR grant 2004069479_002. The authors have no conflicts of interest that are directly relevant to the content of this review.
PY - 2006
Y1 - 2006
N2 - The understanding of molecular mechanisms of complex physiological phenomena, such as cardiac contractile function or blood pressure homeostasis, has generated the need for a new generation of scientists who must be able to conjugate intrinsic biological mechanisms and clinical manifestations of disease. From this body of knowledge new strategies of disease management or therapeutic tools are derived, creating the ground for translational medicine, which provides the bridge from basic science to the medical arena. The investigation of G protein-coupled receptor kinases in the cardiovascular system is one example of the successful transposition of basic science to the field of heart and vascular disorders. This review attempts to assemble the currently available information in this continuing area of research for the class of scientists now referred to as 'translational researchers'.
AB - The understanding of molecular mechanisms of complex physiological phenomena, such as cardiac contractile function or blood pressure homeostasis, has generated the need for a new generation of scientists who must be able to conjugate intrinsic biological mechanisms and clinical manifestations of disease. From this body of knowledge new strategies of disease management or therapeutic tools are derived, creating the ground for translational medicine, which provides the bridge from basic science to the medical arena. The investigation of G protein-coupled receptor kinases in the cardiovascular system is one example of the successful transposition of basic science to the field of heart and vascular disorders. This review attempts to assemble the currently available information in this continuing area of research for the class of scientists now referred to as 'translational researchers'.
UR - http://www.scopus.com/inward/record.url?scp=33846312846&partnerID=8YFLogxK
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U2 - 10.2165/00151642-200613040-00002
DO - 10.2165/00151642-200613040-00002
M3 - Review article
AN - SCOPUS:33846312846
SN - 1120-9879
VL - 13
SP - 151
EP - 158
JO - High Blood Pressure and Cardiovascular Prevention
JF - High Blood Pressure and Cardiovascular Prevention
IS - 4
ER -