Fyn kinase function in lipid utilization: A new upstream regulator of AMPK activity?

Manu Vatish, Eijiro Yamada, Jeffrey E. Pessin, Claire C. Bastie

Research output: Contribution to journalReview articlepeer-review

9 Scopus citations

Abstract

The balance of cellular energy levels in response to changes of nutrient availability, stress stimuli or exercise is a critical step in maintaining tissue and whole body homeostasis. Disruption of this balance is associated with various pathologies, including the metabolic syndrome. Recently, accumulating evidence has demonstrated that the AMP-activated protein kinase (AMPK) plays a central role in sensing changes in energy levels. The regulation of AMPK activity is currently the subject of significant investigation since this enzyme is a potential therapeutic target in both metabolic disorders and tumorigenesis. In this review, we present novel evidence of crosstalk between Fyn, one member of the Src kinase family, and AMPK.

Original languageEnglish (US)
Pages (from-to)191-198
Number of pages8
JournalArchives of Physiology and Biochemistry
Volume115
Issue number4
DOIs
StatePublished - Oct 2009

Keywords

  • AMPK
  • Fyn kinase
  • Homeostasis
  • LKB1
  • Lipid metabolism

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

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