Further observations on the effects of lead implantation in rat brains

Asao Hirano, Joseph A. Kochen

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


Lead pellets were implanted into the forebrains of adult rats. Various cytoplasmic inclusions were found in macrophages, astrocytes, pericytes and microglia. Certain macrophages and reactive astrocytes displayed intranuclear inclusions as well. The hypothalamus, in some of the animals, showed sponginess which proved to be the result of swollen axons.

Original languageEnglish (US)
Pages (from-to)87-93
Number of pages7
JournalActa neuropathologica
Issue number2
StatePublished - Jun 1 1976


  • Axonal swelling
  • Intranuclear inclusions
  • Lead
  • Macrophages

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Clinical Neurology
  • Cellular and Molecular Neuroscience


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