Further evidence for the association between G72/G30 genes and schizophrenia in two ethnically distinct populations

J. Ma, W. Qin, X. Y. Wang, T. W. Guo, L. Bian, S. W. Duan, X. W. Li, F. G. Zou, Y. R. Fang, J. X. Fang, G. Y. Feng, N. F. Gu, D. St Clair, L. He

Research output: Contribution to journalArticle

57 Citations (Scopus)

Abstract

Recently, the nested genes G72 and G30 on chromosome 13q32-q33 have been implicated in the etiology of schizophrenia. We genotyped six single-nucleotide polymorphisms (SNPs: rs3916965, rs3916967, rs2391191, rs778294, rs779293 and rs3918342), which span approximately 82.5 kb in the region encompassing the G72/G30 genes in 1176 Han Chinese subjects (588 cases and 588 controls) and 365 Scottish subjects (183 cases and 182 controls). Significant association between an allele of marker rs778293 and schizophrenia was found in our Chinese samples (P = 0.0013), and was replicated in the Scottish samples (P = 0.022). LD analysis revealed that four SNPs between rs3916965 and rs778294 were in LD, called block I, and the two distal SNPs (rs778293 and rs3918342) constituted a block II in both the Chinese and Scottish samples. We selected one SNP from each block (rs778294 from block I and rs778293 from block II), and then analyzed the haplotypes. A significant difference was observed for the common haplotype GC in the Chinese sample (P = 0.0145), and was replicated in the Scottish sample (P = 0.003). On meta-analysis, we separately analyzed the studies in Asian and European populations because of significant heterogeneity in the homogeneity test. We found a statistically significant association between rs778293 and schizophrenia in Asian populations, but no difference was found between cases and controls in the European populations. Overall, our data give further support to the existing evidence that G72/G30 genes are involved in conferring susceptibility to schizophrenia.

Original languageEnglish (US)
Pages (from-to)479-487
Number of pages9
JournalMolecular Psychiatry
Volume11
Issue number5
DOIs
StatePublished - May 2006
Externally publishedYes

Fingerprint

Single Nucleotide Polymorphism
Schizophrenia
Population
Genes
Haplotypes
Nested Genes
Meta-Analysis
Chromosomes
Alleles

Keywords

  • Association
  • G72
  • Haplotype
  • Meta-analysis
  • Schizophrenia
  • SNP

ASJC Scopus subject areas

  • Molecular Biology
  • Psychiatry and Mental health

Cite this

Further evidence for the association between G72/G30 genes and schizophrenia in two ethnically distinct populations. / Ma, J.; Qin, W.; Wang, X. Y.; Guo, T. W.; Bian, L.; Duan, S. W.; Li, X. W.; Zou, F. G.; Fang, Y. R.; Fang, J. X.; Feng, G. Y.; Gu, N. F.; St Clair, D.; He, L.

In: Molecular Psychiatry, Vol. 11, No. 5, 05.2006, p. 479-487.

Research output: Contribution to journalArticle

Ma, J, Qin, W, Wang, XY, Guo, TW, Bian, L, Duan, SW, Li, XW, Zou, FG, Fang, YR, Fang, JX, Feng, GY, Gu, NF, St Clair, D & He, L 2006, 'Further evidence for the association between G72/G30 genes and schizophrenia in two ethnically distinct populations', Molecular Psychiatry, vol. 11, no. 5, pp. 479-487. https://doi.org/10.1038/sj.mp.4001788
Ma, J. ; Qin, W. ; Wang, X. Y. ; Guo, T. W. ; Bian, L. ; Duan, S. W. ; Li, X. W. ; Zou, F. G. ; Fang, Y. R. ; Fang, J. X. ; Feng, G. Y. ; Gu, N. F. ; St Clair, D. ; He, L. / Further evidence for the association between G72/G30 genes and schizophrenia in two ethnically distinct populations. In: Molecular Psychiatry. 2006 ; Vol. 11, No. 5. pp. 479-487.
@article{15a4bf94881d4a83a4cd1c6adf9807e2,
title = "Further evidence for the association between G72/G30 genes and schizophrenia in two ethnically distinct populations",
abstract = "Recently, the nested genes G72 and G30 on chromosome 13q32-q33 have been implicated in the etiology of schizophrenia. We genotyped six single-nucleotide polymorphisms (SNPs: rs3916965, rs3916967, rs2391191, rs778294, rs779293 and rs3918342), which span approximately 82.5 kb in the region encompassing the G72/G30 genes in 1176 Han Chinese subjects (588 cases and 588 controls) and 365 Scottish subjects (183 cases and 182 controls). Significant association between an allele of marker rs778293 and schizophrenia was found in our Chinese samples (P = 0.0013), and was replicated in the Scottish samples (P = 0.022). LD analysis revealed that four SNPs between rs3916965 and rs778294 were in LD, called block I, and the two distal SNPs (rs778293 and rs3918342) constituted a block II in both the Chinese and Scottish samples. We selected one SNP from each block (rs778294 from block I and rs778293 from block II), and then analyzed the haplotypes. A significant difference was observed for the common haplotype GC in the Chinese sample (P = 0.0145), and was replicated in the Scottish sample (P = 0.003). On meta-analysis, we separately analyzed the studies in Asian and European populations because of significant heterogeneity in the homogeneity test. We found a statistically significant association between rs778293 and schizophrenia in Asian populations, but no difference was found between cases and controls in the European populations. Overall, our data give further support to the existing evidence that G72/G30 genes are involved in conferring susceptibility to schizophrenia.",
keywords = "Association, G72, Haplotype, Meta-analysis, Schizophrenia, SNP",
author = "J. Ma and W. Qin and Wang, {X. Y.} and Guo, {T. W.} and L. Bian and Duan, {S. W.} and Li, {X. W.} and Zou, {F. G.} and Fang, {Y. R.} and Fang, {J. X.} and Feng, {G. Y.} and Gu, {N. F.} and {St Clair}, D. and L. He",
year = "2006",
month = "5",
doi = "10.1038/sj.mp.4001788",
language = "English (US)",
volume = "11",
pages = "479--487",
journal = "Molecular Psychiatry",
issn = "1359-4184",
publisher = "Nature Publishing Group",
number = "5",

}

TY - JOUR

T1 - Further evidence for the association between G72/G30 genes and schizophrenia in two ethnically distinct populations

AU - Ma, J.

AU - Qin, W.

AU - Wang, X. Y.

AU - Guo, T. W.

AU - Bian, L.

AU - Duan, S. W.

AU - Li, X. W.

AU - Zou, F. G.

AU - Fang, Y. R.

AU - Fang, J. X.

AU - Feng, G. Y.

AU - Gu, N. F.

AU - St Clair, D.

AU - He, L.

PY - 2006/5

Y1 - 2006/5

N2 - Recently, the nested genes G72 and G30 on chromosome 13q32-q33 have been implicated in the etiology of schizophrenia. We genotyped six single-nucleotide polymorphisms (SNPs: rs3916965, rs3916967, rs2391191, rs778294, rs779293 and rs3918342), which span approximately 82.5 kb in the region encompassing the G72/G30 genes in 1176 Han Chinese subjects (588 cases and 588 controls) and 365 Scottish subjects (183 cases and 182 controls). Significant association between an allele of marker rs778293 and schizophrenia was found in our Chinese samples (P = 0.0013), and was replicated in the Scottish samples (P = 0.022). LD analysis revealed that four SNPs between rs3916965 and rs778294 were in LD, called block I, and the two distal SNPs (rs778293 and rs3918342) constituted a block II in both the Chinese and Scottish samples. We selected one SNP from each block (rs778294 from block I and rs778293 from block II), and then analyzed the haplotypes. A significant difference was observed for the common haplotype GC in the Chinese sample (P = 0.0145), and was replicated in the Scottish sample (P = 0.003). On meta-analysis, we separately analyzed the studies in Asian and European populations because of significant heterogeneity in the homogeneity test. We found a statistically significant association between rs778293 and schizophrenia in Asian populations, but no difference was found between cases and controls in the European populations. Overall, our data give further support to the existing evidence that G72/G30 genes are involved in conferring susceptibility to schizophrenia.

AB - Recently, the nested genes G72 and G30 on chromosome 13q32-q33 have been implicated in the etiology of schizophrenia. We genotyped six single-nucleotide polymorphisms (SNPs: rs3916965, rs3916967, rs2391191, rs778294, rs779293 and rs3918342), which span approximately 82.5 kb in the region encompassing the G72/G30 genes in 1176 Han Chinese subjects (588 cases and 588 controls) and 365 Scottish subjects (183 cases and 182 controls). Significant association between an allele of marker rs778293 and schizophrenia was found in our Chinese samples (P = 0.0013), and was replicated in the Scottish samples (P = 0.022). LD analysis revealed that four SNPs between rs3916965 and rs778294 were in LD, called block I, and the two distal SNPs (rs778293 and rs3918342) constituted a block II in both the Chinese and Scottish samples. We selected one SNP from each block (rs778294 from block I and rs778293 from block II), and then analyzed the haplotypes. A significant difference was observed for the common haplotype GC in the Chinese sample (P = 0.0145), and was replicated in the Scottish sample (P = 0.003). On meta-analysis, we separately analyzed the studies in Asian and European populations because of significant heterogeneity in the homogeneity test. We found a statistically significant association between rs778293 and schizophrenia in Asian populations, but no difference was found between cases and controls in the European populations. Overall, our data give further support to the existing evidence that G72/G30 genes are involved in conferring susceptibility to schizophrenia.

KW - Association

KW - G72

KW - Haplotype

KW - Meta-analysis

KW - Schizophrenia

KW - SNP

UR - http://www.scopus.com/inward/record.url?scp=33646351759&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33646351759&partnerID=8YFLogxK

U2 - 10.1038/sj.mp.4001788

DO - 10.1038/sj.mp.4001788

M3 - Article

C2 - 16402132

AN - SCOPUS:33646351759

VL - 11

SP - 479

EP - 487

JO - Molecular Psychiatry

JF - Molecular Psychiatry

SN - 1359-4184

IS - 5

ER -