Fungal melanin: What do we know about structure?

Joshua D. Nosanchuk, Ruth E. Stark, Arturo Casadevall

Research output: Contribution to journalArticle

70 Scopus citations

Abstract

The production of melanin significantly enhances the virulence of many important human pathogenic fungi. Despite fungal melanin's importance in human disease, as well as melanin's contribution to the ability of fungi to survive in diverse hostile environments, the structure of melanin remains unsolved. Nevertheless, ongoing research efforts have progressively revealed several notable structural characteristics of this enigmatic pigment, which will be the focus of this review. These compositional and organizational insights could further our ability to develop novel therapeutic approaches to combat fungal disease and enhance our understanding of how melanin is inserted into the cell wall.

Original languageEnglish (US)
Article number01463
JournalFrontiers in Microbiology
Volume6
Issue numberDEC
DOIs
StatePublished - 2015

    Fingerprint

Keywords

  • Cryptococcus
  • Fungal virulence
  • Fungi
  • Melanin
  • Structure

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)

Cite this