Fungal killing by mammalian phagocytic cells

André Moraes Nicola, Arturo Casadevall, David L. Goldman

Research output: Contribution to journalReview article

30 Scopus citations

Abstract

Phagocytes are considered the most important effector cells in the immune response against fungal infections. To exert their role, they must recognize the invading fungi, internalise, and kill them within the phagosome. Major advances in the field have elucidated the roles of pattern-recognition receptors in the innate immunity sensing and the importance of reactive oxygen and nitrogen species in intracellular killing of fungi. Surprising exit mechanisms for intracellular pathogens and extracellular traps have also been discovered. These and several other recent breakthroughs in our understanding of the mechanisms used by phagocytes to kill fungal pathogens are reviewed in this work.

Original languageEnglish (US)
Pages (from-to)313-317
Number of pages5
JournalCurrent Opinion in Microbiology
Volume11
Issue number4
DOIs
Publication statusPublished - Aug 1 2008

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ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)
  • Infectious Diseases

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