Fungal killing by mammalian phagocytic cells

André Moraes Nicola, Arturo Casadevall, David L. Goldman

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Phagocytes are considered the most important effector cells in the immune response against fungal infections. To exert their role, they must recognize the invading fungi, internalise, and kill them within the phagosome. Major advances in the field have elucidated the roles of pattern-recognition receptors in the innate immunity sensing and the importance of reactive oxygen and nitrogen species in intracellular killing of fungi. Surprising exit mechanisms for intracellular pathogens and extracellular traps have also been discovered. These and several other recent breakthroughs in our understanding of the mechanisms used by phagocytes to kill fungal pathogens are reviewed in this work.

Original languageEnglish (US)
Pages (from-to)313-317
Number of pages5
JournalCurrent Opinion in Microbiology
Volume11
Issue number4
DOIs
StatePublished - Aug 2008

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Phagocytes
Fungi
Pattern Recognition Receptors
Reactive Nitrogen Species
Phagosomes
Mycoses
Innate Immunity
Reactive Oxygen Species
Extracellular Traps

ASJC Scopus subject areas

  • Infectious Diseases
  • Microbiology

Cite this

Fungal killing by mammalian phagocytic cells. / Nicola, André Moraes; Casadevall, Arturo; Goldman, David L.

In: Current Opinion in Microbiology, Vol. 11, No. 4, 08.2008, p. 313-317.

Research output: Contribution to journalArticle

Nicola, André Moraes ; Casadevall, Arturo ; Goldman, David L. / Fungal killing by mammalian phagocytic cells. In: Current Opinion in Microbiology. 2008 ; Vol. 11, No. 4. pp. 313-317.
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