TY - JOUR
T1 - Fungal killing by mammalian phagocytic cells
AU - Nicola, André Moraes
AU - Casadevall, Arturo
AU - Goldman, David L.
N1 - Funding Information:
The authors would like to thank Magdia de Jesus for comments on the manuscript. AC is supported by the National Institutes of Health grants AI33774, HL59842, AI33142 and AI52733.
PY - 2008/8
Y1 - 2008/8
N2 - Phagocytes are considered the most important effector cells in the immune response against fungal infections. To exert their role, they must recognize the invading fungi, internalise, and kill them within the phagosome. Major advances in the field have elucidated the roles of pattern-recognition receptors in the innate immunity sensing and the importance of reactive oxygen and nitrogen species in intracellular killing of fungi. Surprising exit mechanisms for intracellular pathogens and extracellular traps have also been discovered. These and several other recent breakthroughs in our understanding of the mechanisms used by phagocytes to kill fungal pathogens are reviewed in this work.
AB - Phagocytes are considered the most important effector cells in the immune response against fungal infections. To exert their role, they must recognize the invading fungi, internalise, and kill them within the phagosome. Major advances in the field have elucidated the roles of pattern-recognition receptors in the innate immunity sensing and the importance of reactive oxygen and nitrogen species in intracellular killing of fungi. Surprising exit mechanisms for intracellular pathogens and extracellular traps have also been discovered. These and several other recent breakthroughs in our understanding of the mechanisms used by phagocytes to kill fungal pathogens are reviewed in this work.
UR - http://www.scopus.com/inward/record.url?scp=48749102973&partnerID=8YFLogxK
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U2 - 10.1016/j.mib.2008.05.011
DO - 10.1016/j.mib.2008.05.011
M3 - Review article
C2 - 18573683
AN - SCOPUS:48749102973
SN - 1369-5274
VL - 11
SP - 313
EP - 317
JO - Current Opinion in Microbiology
JF - Current Opinion in Microbiology
IS - 4
ER -
