TY - JOUR
T1 - Functions of cofilin in cell locomotion and invasion
AU - Bravo-Cordero, Jose Javier
AU - Magalhaes, Marco A.O.
AU - Eddy, Robert J.
AU - Hodgson, Louis
AU - Condeelis, John
PY - 2013/7
Y1 - 2013/7
N2 - Recently, a consensus has emerged that cofilin severing activity can generate free actin filament ends that are accessible for F-actin polymerization and depolymerization without changing the rate of G-actin association and dissociation at either filament end. The structural basis of actin filament severing by cofilin is now better understood. These results have been integrated with recently discovered mechanisms for cofilin activation in migrating cells, which led to new models for cofilin function that provide insights into how cofilin regulation determines the temporal and spatial control of cell behaviour.
AB - Recently, a consensus has emerged that cofilin severing activity can generate free actin filament ends that are accessible for F-actin polymerization and depolymerization without changing the rate of G-actin association and dissociation at either filament end. The structural basis of actin filament severing by cofilin is now better understood. These results have been integrated with recently discovered mechanisms for cofilin activation in migrating cells, which led to new models for cofilin function that provide insights into how cofilin regulation determines the temporal and spatial control of cell behaviour.
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U2 - 10.1038/nrm3609
DO - 10.1038/nrm3609
M3 - Review article
C2 - 23778968
AN - SCOPUS:84879417563
SN - 1471-0072
VL - 14
SP - 405
EP - 417
JO - Nature Reviews Molecular Cell Biology
JF - Nature Reviews Molecular Cell Biology
IS - 7
ER -