Functions of cofilin in cell locomotion and invasion

Jose Javier Bravo-Cordero, Marco A O Magalhaes, Robert J. Eddy, Louis Hodgson, John S. Condeelis

Research output: Contribution to journalArticle

223 Citations (Scopus)

Abstract

Recently, a consensus has emerged that cofilin severing activity can generate free actin filament ends that are accessible for F-actin polymerization and depolymerization without changing the rate of G-actin association and dissociation at either filament end. The structural basis of actin filament severing by cofilin is now better understood. These results have been integrated with recently discovered mechanisms for cofilin activation in migrating cells, which led to new models for cofilin function that provide insights into how cofilin regulation determines the temporal and spatial control of cell behaviour.

Original languageEnglish (US)
Pages (from-to)405-417
Number of pages13
JournalNature Reviews Molecular Cell Biology
Volume14
Issue number7
DOIs
StatePublished - Jul 2013

Fingerprint

Actin Depolymerizing Factors
Cell Movement
Actin Cytoskeleton
Actins
Behavior Control
Polymerization
Consensus

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

Cite this

Functions of cofilin in cell locomotion and invasion. / Bravo-Cordero, Jose Javier; Magalhaes, Marco A O; Eddy, Robert J.; Hodgson, Louis; Condeelis, John S.

In: Nature Reviews Molecular Cell Biology, Vol. 14, No. 7, 07.2013, p. 405-417.

Research output: Contribution to journalArticle

@article{9ec2c9c3511b4ed381260a19b3772600,
title = "Functions of cofilin in cell locomotion and invasion",
abstract = "Recently, a consensus has emerged that cofilin severing activity can generate free actin filament ends that are accessible for F-actin polymerization and depolymerization without changing the rate of G-actin association and dissociation at either filament end. The structural basis of actin filament severing by cofilin is now better understood. These results have been integrated with recently discovered mechanisms for cofilin activation in migrating cells, which led to new models for cofilin function that provide insights into how cofilin regulation determines the temporal and spatial control of cell behaviour.",
author = "Bravo-Cordero, {Jose Javier} and Magalhaes, {Marco A O} and Eddy, {Robert J.} and Louis Hodgson and Condeelis, {John S.}",
year = "2013",
month = "7",
doi = "10.1038/nrm3609",
language = "English (US)",
volume = "14",
pages = "405--417",
journal = "Nature Reviews Molecular Cell Biology",
issn = "1471-0072",
publisher = "Nature Publishing Group",
number = "7",

}

TY - JOUR

T1 - Functions of cofilin in cell locomotion and invasion

AU - Bravo-Cordero, Jose Javier

AU - Magalhaes, Marco A O

AU - Eddy, Robert J.

AU - Hodgson, Louis

AU - Condeelis, John S.

PY - 2013/7

Y1 - 2013/7

N2 - Recently, a consensus has emerged that cofilin severing activity can generate free actin filament ends that are accessible for F-actin polymerization and depolymerization without changing the rate of G-actin association and dissociation at either filament end. The structural basis of actin filament severing by cofilin is now better understood. These results have been integrated with recently discovered mechanisms for cofilin activation in migrating cells, which led to new models for cofilin function that provide insights into how cofilin regulation determines the temporal and spatial control of cell behaviour.

AB - Recently, a consensus has emerged that cofilin severing activity can generate free actin filament ends that are accessible for F-actin polymerization and depolymerization without changing the rate of G-actin association and dissociation at either filament end. The structural basis of actin filament severing by cofilin is now better understood. These results have been integrated with recently discovered mechanisms for cofilin activation in migrating cells, which led to new models for cofilin function that provide insights into how cofilin regulation determines the temporal and spatial control of cell behaviour.

UR - http://www.scopus.com/inward/record.url?scp=84879417563&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84879417563&partnerID=8YFLogxK

U2 - 10.1038/nrm3609

DO - 10.1038/nrm3609

M3 - Article

C2 - 23778968

AN - SCOPUS:84879417563

VL - 14

SP - 405

EP - 417

JO - Nature Reviews Molecular Cell Biology

JF - Nature Reviews Molecular Cell Biology

SN - 1471-0072

IS - 7

ER -