Functions of cofilin in cell locomotion and invasion

Jose Javier Bravo-Cordero, Marco A.O. Magalhaes, Robert J. Eddy, Louis Hodgson, John Condeelis

Research output: Contribution to journalReview articlepeer-review

332 Scopus citations


Recently, a consensus has emerged that cofilin severing activity can generate free actin filament ends that are accessible for F-actin polymerization and depolymerization without changing the rate of G-actin association and dissociation at either filament end. The structural basis of actin filament severing by cofilin is now better understood. These results have been integrated with recently discovered mechanisms for cofilin activation in migrating cells, which led to new models for cofilin function that provide insights into how cofilin regulation determines the temporal and spatial control of cell behaviour.

Original languageEnglish (US)
Pages (from-to)405-417
Number of pages13
JournalNature Reviews Molecular Cell Biology
Issue number7
StatePublished - Jul 2013

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology


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