TY - JOUR
T1 - Functions and importance of mycobacterial extracellular vesicles
AU - Rodriguez, G. Marcela
AU - Prados-Rosales, Rafael
N1 - Publisher Copyright:
© 2016, Springer-Verlag Berlin Heidelberg.
PY - 2016/5/1
Y1 - 2016/5/1
N2 - The release of cellular factors by means of extracellular vesicles (EVs) is conserved in archaea, bacteria, and eukaryotes. EVs are released by growing bacteria as part of their interaction with their environment and, for pathogenic bacteria, constitute an important component of their interactions with the host. While EVs released by gram-negative bacteria have been extensively studied, the vesicles released by thick cell wall microorganisms like mycobacteria were recognized only recently and are less well understood. Nonetheless, studies of mycobacterial EVs have already suggested roles in pathogenesis, opening exciting new avenues of research aimed at understanding their biogenesis and potential use in antitubercular strategies. In this minireview, we discuss the discovery of mycobacterial vesicles, the current understanding of their nature, content, regulation, and possible functions, as well as their potential therapeutic applications.
AB - The release of cellular factors by means of extracellular vesicles (EVs) is conserved in archaea, bacteria, and eukaryotes. EVs are released by growing bacteria as part of their interaction with their environment and, for pathogenic bacteria, constitute an important component of their interactions with the host. While EVs released by gram-negative bacteria have been extensively studied, the vesicles released by thick cell wall microorganisms like mycobacteria were recognized only recently and are less well understood. Nonetheless, studies of mycobacterial EVs have already suggested roles in pathogenesis, opening exciting new avenues of research aimed at understanding their biogenesis and potential use in antitubercular strategies. In this minireview, we discuss the discovery of mycobacterial vesicles, the current understanding of their nature, content, regulation, and possible functions, as well as their potential therapeutic applications.
KW - Iron
KW - Lipoproteins
KW - Mycobacterium
KW - Siderophores
KW - Vaccines
KW - Vesicles
UR - http://www.scopus.com/inward/record.url?scp=84961627538&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84961627538&partnerID=8YFLogxK
U2 - 10.1007/s00253-016-7484-x
DO - 10.1007/s00253-016-7484-x
M3 - Review article
AN - SCOPUS:84961627538
SN - 0175-7598
VL - 100
SP - 3887
EP - 3892
JO - Applied Microbiology and Biotechnology
JF - Applied Microbiology and Biotechnology
IS - 9
ER -