Functions and importance of mycobacterial extracellular vesicles

G. Marcela Rodriguez, Rafael Prados-Rosales

Research output: Contribution to journalReview article

10 Scopus citations

Abstract

The release of cellular factors by means of extracellular vesicles (EVs) is conserved in archaea, bacteria, and eukaryotes. EVs are released by growing bacteria as part of their interaction with their environment and, for pathogenic bacteria, constitute an important component of their interactions with the host. While EVs released by gram-negative bacteria have been extensively studied, the vesicles released by thick cell wall microorganisms like mycobacteria were recognized only recently and are less well understood. Nonetheless, studies of mycobacterial EVs have already suggested roles in pathogenesis, opening exciting new avenues of research aimed at understanding their biogenesis and potential use in antitubercular strategies. In this minireview, we discuss the discovery of mycobacterial vesicles, the current understanding of their nature, content, regulation, and possible functions, as well as their potential therapeutic applications.

Original languageEnglish (US)
Pages (from-to)3887-3892
Number of pages6
JournalApplied Microbiology and Biotechnology
Volume100
Issue number9
DOIs
Publication statusPublished - May 1 2016

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Keywords

  • Iron
  • Lipoproteins
  • Mycobacterium
  • Siderophores
  • Vaccines
  • Vesicles

ASJC Scopus subject areas

  • Biotechnology
  • Applied Microbiology and Biotechnology

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