Functionally Relevant RNA Helicase Mutations in Familial and Sporadic Myeloid Malignancies

Iléana Antony-Debré, Ulrich Steidl

Research output: Contribution to journalShort survey

4 Scopus citations

Abstract

In this issue of Cancer Cell, Polprasert and colleagues identified recurrent mutations in the DEAD/H-box RNA helicase gene DDX41 in familial and acquired cases of myelodsyplasia and acute myeloid leukemia. These mutations induce defects in RNA splicing and represent a new class of mutations in myeloid malignancies.

Original languageEnglish (US)
Pages (from-to)609-611
Number of pages3
JournalCancer Cell
Volume27
Issue number5
DOIs
StatePublished - May 11 2015

ASJC Scopus subject areas

  • Oncology
  • Cell Biology
  • Cancer Research

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