Abstract
The reaction of commercially available 5-iodouracil with 2 equiv of MeMgCl in the presence of LiCl, followed by the addition of i-PrMgCl-LiCl, provides the corresponding trimagnesiated species, which reacts with various electrophiles to give selectively 5-functionalized uracil derivatives. This method was also successfully applied to the functionalization of 6-iodouracils including the synthesis of pharmaceutically relevant Emivirine and HEPT precursors.
Original language | English (US) |
---|---|
Pages (from-to) | 1639-1641 |
Number of pages | 3 |
Journal | Organic Letters |
Volume | 9 |
Issue number | 9 |
DOIs | |
State | Published - Apr 26 2007 |
Externally published | Yes |
ASJC Scopus subject areas
- Biochemistry
- Physical and Theoretical Chemistry
- Organic Chemistry