Functional role of mitochondria in arrhythmogenesis

Jessica Gambardella; Daniela Sorriento; Michele Ciccarelli; Carmine Del Giudice; Antonella Fiordelisi; Luigi Napolitano; Bruno Trimarco; Guido Iaccarino; Gaetano Santulli

doi:10.1007/978-3-319-55330-6_10

Functional role of mitochondria in arrhythmogenesis

Jessica Gambardella, Daniela Sorriento, Michele Ciccarelli, Carmine Del Giudice, Antonella Fiordelisi, Luigi Napolitano, Bruno Trimarco, Guido Iaccarino, Gaetano Santulli

Research output: Chapter in Book/Report/Conference proceeding › Chapter

46 Scopus citations

Abstract

Growing evidence indicate that mitochondria play a functional role in arrhythmogenesis. We report here the molecular mechanisms underlying the action of these highly dynamic organelles in the regulation of cell metabolism, action potential and, overall, heart excitability. In particular, we examine the role of cardiac mitochondria in linking metabolism and cell excitability. The importance of the main mitochondrial channels is evaluated as well, including the recently identified calcium uniporter. Promises and pitfalls of potential therapeutic strategies targeting mitochondrial pathways are also assessed.

Original language	English (US)
Title of host publication	Advances in Experimental Medicine and Biology
Publisher	Springer New York LLC
Pages	191-202
Number of pages	12
DOIs	https://doi.org/10.1007/978-3-319-55330-6_10
State	Published - May 1 2017
Externally published	Yes

Publication series

Name	Advances in Experimental Medicine and Biology
Volume	982
ISSN (Print)	0065-2598
ISSN (Electronic)	2214-8019

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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10.1007/978-3-319-55330-6_10

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Gambardella, J., Sorriento, D., Ciccarelli, M., Del Giudice, C., Fiordelisi, A., Napolitano, L., Trimarco, B., Iaccarino, G., & Santulli, G. (2017). Functional role of mitochondria in arrhythmogenesis. In Advances in Experimental Medicine and Biology (pp. 191-202). (Advances in Experimental Medicine and Biology; Vol. 982). Springer New York LLC. https://doi.org/10.1007/978-3-319-55330-6_10

Gambardella, J, Sorriento, D, Ciccarelli, M, Del Giudice, C, Fiordelisi, A, Napolitano, L, Trimarco, B, Iaccarino, G & Santulli, G 2017, Functional role of mitochondria in arrhythmogenesis. in Advances in Experimental Medicine and Biology. Advances in Experimental Medicine and Biology, vol. 982, Springer New York LLC, pp. 191-202. https://doi.org/10.1007/978-3-319-55330-6_10

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AU - Gambardella, Jessica

AU - Sorriento, Daniela

AU - Ciccarelli, Michele

AU - Del Giudice, Carmine

AU - Fiordelisi, Antonella

AU - Napolitano, Luigi

AU - Trimarco, Bruno

AU - Iaccarino, Guido

AU - Santulli, Gaetano

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AB - Growing evidence indicate that mitochondria play a functional role in arrhythmogenesis. We report here the molecular mechanisms underlying the action of these highly dynamic organelles in the regulation of cell metabolism, action potential and, overall, heart excitability. In particular, we examine the role of cardiac mitochondria in linking metabolism and cell excitability. The importance of the main mitochondrial channels is evaluated as well, including the recently identified calcium uniporter. Promises and pitfalls of potential therapeutic strategies targeting mitochondrial pathways are also assessed.

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Functional role of mitochondria in arrhythmogenesis

Abstract

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