Functional role of mitochondria in arrhythmogenesis

Jessica Gambardella, Daniela Sorriento, Michele Ciccarelli, Carmine Del Giudice, Antonella Fiordelisi, Luigi Napolitano, Bruno Trimarco, Guido Iaccarino, Gaetano Santulli

Research output: Chapter in Book/Report/Conference proceedingChapter

14 Scopus citations

Abstract

Growing evidence indicate that mitochondria play a functional role in arrhythmogenesis. We report here the molecular mechanisms underlying the action of these highly dynamic organelles in the regulation of cell metabolism, action potential and, overall, heart excitability. In particular, we examine the role of cardiac mitochondria in linking metabolism and cell excitability. The importance of the main mitochondrial channels is evaluated as well, including the recently identified calcium uniporter. Promises and pitfalls of potential therapeutic strategies targeting mitochondrial pathways are also assessed.

Original languageEnglish (US)
Title of host publicationAdvances in Experimental Medicine and Biology
PublisherSpringer New York LLC
Pages191-202
Number of pages12
DOIs
StatePublished - May 1 2017
Externally publishedYes

Publication series

NameAdvances in Experimental Medicine and Biology
Volume982
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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  • Cite this

    Gambardella, J., Sorriento, D., Ciccarelli, M., Del Giudice, C., Fiordelisi, A., Napolitano, L., Trimarco, B., Iaccarino, G., & Santulli, G. (2017). Functional role of mitochondria in arrhythmogenesis. In Advances in Experimental Medicine and Biology (pp. 191-202). (Advances in Experimental Medicine and Biology; Vol. 982). Springer New York LLC. https://doi.org/10.1007/978-3-319-55330-6_10