Functional role of miRNA in cardiac resynchronization therapy

Celestino Sardu, Raffaele Marfella, Gaetano Santulli, Giuseppe Paolisso

Research output: Contribution to journalReview article

34 Scopus citations

Abstract

Heart failure (HF) disease progression is related to numerous adaptive processes including cardiac fibrosis, hypertrophy and apoptosis by activation of the 'fetal' gene program and downregulation of mRNA signatures, suggesting the importance of molecular mechanisms that suppress mRNA steady-state levels. miRNAs (miRs) are small, noncoding RNAs that bind mRNAs at their 3′-UTRs, leading to mRNA degradation or inhibition of protein translation. Several miRs are unregulated in response to cellular stress and can modify cellular functions such as proliferation, differentiation and programmed death; these miRs are also regulated in cardiac disease. Cardiac resynchronization therapy improves cardiac performance and myocardial mechanical efficiency. . In this updated critical appraisal we report on the main miRs that play a key role in response to cardiac resynchronization therapy (i.e., responder vs nonresponder HF patients), focusing on the miR-mediated modulation of cardiac angiogenesis, apoptosis, fibrosis and membrane ionic currents.

Original languageEnglish (US)
Pages (from-to)1159-1168
Number of pages10
JournalPharmacogenomics
Volume15
Issue number8
DOIs
StatePublished - Jun 2014
Externally publishedYes

Keywords

  • CRT
  • HF
  • apoptosis
  • cardiac fibrosis
  • hypertrophy
  • microRNA
  • responder patients

ASJC Scopus subject areas

  • Molecular Medicine
  • Genetics
  • Pharmacology

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  • Cite this

    Sardu, C., Marfella, R., Santulli, G., & Paolisso, G. (2014). Functional role of miRNA in cardiac resynchronization therapy. Pharmacogenomics, 15(8), 1159-1168. https://doi.org/10.2217/pgs.14.76