Functional role of miR-155 in the pathogenesis of diabetes mellitus and its complications

Stanislovas S. Jankauskas, Jessica Gambardella, Celestino Sardu, Angela Lombardi, Gaetano Santulli

Research output: Contribution to journalReview articlepeer-review

9 Scopus citations

Abstract

Substantial evidence indicates that microRNA-155 (miR-155) plays a crucial role in the pathogenesis of diabetes mellitus (DM) and its complications. A number of clinical studies reported low serum levels of miR-155 in patients with type 2 diabetes (T2D). Preclinical studies revealed that miR-155 partakes in the phenotypic switch of cells within the islets of Langerhans under metabolic stress. Moreover, miR-155 was shown to regulate insulin sensitivity in liver, adipose tissue, and skeletal muscle. Dysregulation of miR-155 expression was also shown to predict the development of nephropathy, neuropathy, and retinopathy in DM. Here, we systematically describe the reports investigating the role of miR-155 in DM and its complications. We also discuss the recent results from in vivo and in vitro models of type 1 diabetes (T1D) and T2D, discussing the differences between clinical and preclinical studies and shedding light on the molecular pathways mediated by miR-155 in different tissues affected by DM.

Original languageEnglish (US)
Article number39
JournalNon-coding RNA
Volume7
Issue number3
DOIs
StatePublished - Sep 2021

Keywords

  • Diabetes
  • Epigenetics
  • Inflammation
  • Insulin
  • Islets
  • MafB
  • Metabolic syndrome
  • MiR-155
  • Micro-RNA
  • NF-κB
  • NRF2
  • PBMC
  • β-cells

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Genetics

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