TY - JOUR
T1 - Functional Role of microRNAs in Regulating Cardiomyocyte Death
AU - Kansakar, Urna
AU - Varzideh, Fahimeh
AU - Mone, Pasquale
AU - Jankauskas, Stanislovas S.
AU - Santulli, Gaetano
N1 - Funding Information:
The Santulli’s Lab is supported in part by the National Institutes of Health (NIH: R01-HL159062, R01-DK123259, R01-HL146691, R01-DK033823, R56-AG066431, T32-HL144456, and R00-DK107895, to G.S.), by the Irma T. Hirschl and Monique Weill-Caulier Trusts (to G.S.), and by the Diabetes Action Research and Education Foundation (to G.S.); F.V. and S.S.J. hold postdoctoral fellowships from the American Heart Association (AHA-22POST915561 and AHA-21POST836407, respectively).
Publisher Copyright:
© 2022 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2022/3/1
Y1 - 2022/3/1
N2 - microRNAs (miRNA, miRs) play crucial roles in cardiovascular disease regulating numer-ous processes, including inflammation, cell proliferation, angiogenesis, and cell death. Herein, we present an updated and comprehensive overview of the functional involvement of miRs in the regulation of cardiomyocyte death, a central event in acute myocardial infarction, ischemia/reperfusion, and heart failure. Specifically, in this systematic review we are focusing on necrosis, apoptosis, and autophagy.
AB - microRNAs (miRNA, miRs) play crucial roles in cardiovascular disease regulating numer-ous processes, including inflammation, cell proliferation, angiogenesis, and cell death. Herein, we present an updated and comprehensive overview of the functional involvement of miRs in the regulation of cardiomyocyte death, a central event in acute myocardial infarction, ischemia/reperfusion, and heart failure. Specifically, in this systematic review we are focusing on necrosis, apoptosis, and autophagy.
KW - Apoptosis
KW - Autophagy
KW - Cardiomyocytes
KW - Cell death
KW - Heart failure
KW - Ischemia/reperfusion
KW - Myocardial infarction
KW - Necrosis
KW - Non-coding RNA
UR - http://www.scopus.com/inward/record.url?scp=85126317981&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85126317981&partnerID=8YFLogxK
U2 - 10.3390/cells11060983
DO - 10.3390/cells11060983
M3 - Review article
C2 - 35326433
AN - SCOPUS:85126317981
SN - 2073-4409
VL - 11
JO - Cells
JF - Cells
IS - 6
M1 - 983
ER -
