Functional Role of microRNAs in Regulating Cardiomyocyte Death

Urna Kansakar, Fahimeh Varzideh, Pasquale Mone, Stanislovas S. Jankauskas, Gaetano Santulli

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations

Abstract

microRNAs (miRNA, miRs) play crucial roles in cardiovascular disease regulating numer-ous processes, including inflammation, cell proliferation, angiogenesis, and cell death. Herein, we present an updated and comprehensive overview of the functional involvement of miRs in the regulation of cardiomyocyte death, a central event in acute myocardial infarction, ischemia/reperfusion, and heart failure. Specifically, in this systematic review we are focusing on necrosis, apoptosis, and autophagy.

Original languageEnglish (US)
Article number983
JournalCells
Volume11
Issue number6
DOIs
StatePublished - Mar 1 2022

Keywords

  • Apoptosis
  • Autophagy
  • Cardiomyocytes
  • Cell death
  • Heart failure
  • Ischemia/reperfusion
  • Myocardial infarction
  • Necrosis
  • Non-coding RNA

ASJC Scopus subject areas

  • Medicine(all)

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