Functional organization of neuronal and humoral signals regulating feeding behavior

Gary J. Schwartz, Lori M. Zeltser

Research output: Contribution to journalArticlepeer-review

45 Scopus citations


Energy homeostasis-ensuring that energy availability matches energy requirements-is essential for survival. One way that energy balance is achieved is through coordinated action of neural and neuroendocrine feeding circuits, which promote energy intake when energy supply is limited. Feeding behavior engages multiple somatic and visceral tissues distributed throughout the body-contraction of skeletal and smooth muscles in the head and along the upper digestive tract required to consume and digest food, as well as stimulation of endocrine and exocrine secretions from a wide range of organs. Accordingly, neurons that contribute to feeding behaviors are localized to central, peripheral, and enteric nervous systems. To promote energy balance, feeding circuits must be able to identify and respond to energy requirements, as well as the amount of energy available from internal and external sources, and then direct appropriate coordinated responses throughout the body.

Original languageEnglish (US)
Pages (from-to)1-21
Number of pages21
JournalAnnual Review of Nutrition
StatePublished - Jul 2013


  • CNS circuits
  • Energy balance
  • Food intake
  • Obesity

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics


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