TY - JOUR
T1 - Functional interrelationship of serotonin and norepinephrine
T2 - Cortisol response to MCPP and DMI in patients with panic disorder, patients with depression, and normal control subjects
AU - Asnis, Gregory M.
AU - Wetzler, Scott
AU - Sanderson, William C.
AU - Kahn, RenéS S.
AU - van Praag, Herman M.
N1 - Funding Information:
Acknowledgment. This recearchw ass upportedin part by NationalI nstitute Health grant ROI-38807 to G.M.A.
PY - 1992/7
Y1 - 1992/7
N2 - The relationship between norepinephrine (NE) and serotonin (5-hydroxytryptamine; 5HT) functioning was explored in a neuroendocrine challenge paradigm. Ten normal control subjects, 17 patients with major depression, and 22 patients with panic disorder volunteered to participate in this study. Each subject received a challenge with meta-chlorophenylpiperazine (MCPP; 0.25 mg/kg, p.o.), a 5HT agonist, and desmethylimipramine (DMI; 75 mg, i.m.), an indirect NE agonist, in randomized order. The peak-minus-baseline cortisol response to MCPP was used as an indicator of 5HT function, and cortisol response at 75 minutes-minus-baseline to DMI was used as an indicator of NE function. The cortisol responses to DMI and MCPP were found to be highly negatively correlated in the total sample, in particular in the patients with major depression and panic disorder. This findings suggests that the functions (or dysfunctions) of the NE and 5HT systems may not be separate as is usually believed, and that the NE and 5HT disturbances observed in major depression and panic disorder may not be independent. Rather, there may be a joint disturbance of NE-5HT in these disorders.
AB - The relationship between norepinephrine (NE) and serotonin (5-hydroxytryptamine; 5HT) functioning was explored in a neuroendocrine challenge paradigm. Ten normal control subjects, 17 patients with major depression, and 22 patients with panic disorder volunteered to participate in this study. Each subject received a challenge with meta-chlorophenylpiperazine (MCPP; 0.25 mg/kg, p.o.), a 5HT agonist, and desmethylimipramine (DMI; 75 mg, i.m.), an indirect NE agonist, in randomized order. The peak-minus-baseline cortisol response to MCPP was used as an indicator of 5HT function, and cortisol response at 75 minutes-minus-baseline to DMI was used as an indicator of NE function. The cortisol responses to DMI and MCPP were found to be highly negatively correlated in the total sample, in particular in the patients with major depression and panic disorder. This findings suggests that the functions (or dysfunctions) of the NE and 5HT systems may not be separate as is usually believed, and that the NE and 5HT disturbances observed in major depression and panic disorder may not be independent. Rather, there may be a joint disturbance of NE-5HT in these disorders.
KW - Major affective disorder
KW - anxiety
KW - desmethylimipramine
KW - meta-chlorophenylpiperazine
KW - psychoneuroendocrine challenges
UR - http://www.scopus.com/inward/record.url?scp=0026793388&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0026793388&partnerID=8YFLogxK
U2 - 10.1016/0165-1781(92)90142-P
DO - 10.1016/0165-1781(92)90142-P
M3 - Article
C2 - 1438618
AN - SCOPUS:0026793388
SN - 0165-1781
VL - 43
SP - 65
EP - 76
JO - Psychiatry Research
JF - Psychiatry Research
IS - 1
ER -