Functional interrelationship of serotonin and norepinephrine

Cortisol response to MCPP and DMI in patients with panic disorder, patients with depression, and normal control subjects

Gregory M. Asnis, Scott Wetzler, William C. Sanderson, RenéS Kahn, Herman M. van Praag

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

The relationship between norepinephrine (NE) and serotonin (5-hydroxytryptamine; 5HT) functioning was explored in a neuroendocrine challenge paradigm. Ten normal control subjects, 17 patients with major depression, and 22 patients with panic disorder volunteered to participate in this study. Each subject received a challenge with meta-chlorophenylpiperazine (MCPP; 0.25 mg/kg, p.o.), a 5HT agonist, and desmethylimipramine (DMI; 75 mg, i.m.), an indirect NE agonist, in randomized order. The peak-minus-baseline cortisol response to MCPP was used as an indicator of 5HT function, and cortisol response at 75 minutes-minus-baseline to DMI was used as an indicator of NE function. The cortisol responses to DMI and MCPP were found to be highly negatively correlated in the total sample, in particular in the patients with major depression and panic disorder. This findings suggests that the functions (or dysfunctions) of the NE and 5HT systems may not be separate as is usually believed, and that the NE and 5HT disturbances observed in major depression and panic disorder may not be independent. Rather, there may be a joint disturbance of NE-5HT in these disorders.

Original languageEnglish (US)
Pages (from-to)65-76
Number of pages12
JournalPsychiatry Research
Volume43
Issue number1
DOIs
StatePublished - 1992

Fingerprint

Panic Disorder
Hydrocortisone
Serotonin
Norepinephrine
Depression
Desipramine
Joints

Keywords

  • anxiety
  • desmethylimipramine
  • Major affective disorder
  • meta-chlorophenylpiperazine
  • psychoneuroendocrine challenges

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry
  • Psychology(all)

Cite this

Functional interrelationship of serotonin and norepinephrine : Cortisol response to MCPP and DMI in patients with panic disorder, patients with depression, and normal control subjects. / Asnis, Gregory M.; Wetzler, Scott; Sanderson, William C.; Kahn, RenéS; van Praag, Herman M.

In: Psychiatry Research, Vol. 43, No. 1, 1992, p. 65-76.

Research output: Contribution to journalArticle

@article{858b1b226373400f86e7a835d3fbc8e8,
title = "Functional interrelationship of serotonin and norepinephrine: Cortisol response to MCPP and DMI in patients with panic disorder, patients with depression, and normal control subjects",
abstract = "The relationship between norepinephrine (NE) and serotonin (5-hydroxytryptamine; 5HT) functioning was explored in a neuroendocrine challenge paradigm. Ten normal control subjects, 17 patients with major depression, and 22 patients with panic disorder volunteered to participate in this study. Each subject received a challenge with meta-chlorophenylpiperazine (MCPP; 0.25 mg/kg, p.o.), a 5HT agonist, and desmethylimipramine (DMI; 75 mg, i.m.), an indirect NE agonist, in randomized order. The peak-minus-baseline cortisol response to MCPP was used as an indicator of 5HT function, and cortisol response at 75 minutes-minus-baseline to DMI was used as an indicator of NE function. The cortisol responses to DMI and MCPP were found to be highly negatively correlated in the total sample, in particular in the patients with major depression and panic disorder. This findings suggests that the functions (or dysfunctions) of the NE and 5HT systems may not be separate as is usually believed, and that the NE and 5HT disturbances observed in major depression and panic disorder may not be independent. Rather, there may be a joint disturbance of NE-5HT in these disorders.",
keywords = "anxiety, desmethylimipramine, Major affective disorder, meta-chlorophenylpiperazine, psychoneuroendocrine challenges",
author = "Asnis, {Gregory M.} and Scott Wetzler and Sanderson, {William C.} and Ren{\'e}S Kahn and {van Praag}, {Herman M.}",
year = "1992",
doi = "10.1016/0165-1781(92)90142-P",
language = "English (US)",
volume = "43",
pages = "65--76",
journal = "Psychiatry Research",
issn = "0165-1781",
publisher = "Elsevier Ireland Ltd",
number = "1",

}

TY - JOUR

T1 - Functional interrelationship of serotonin and norepinephrine

T2 - Cortisol response to MCPP and DMI in patients with panic disorder, patients with depression, and normal control subjects

AU - Asnis, Gregory M.

AU - Wetzler, Scott

AU - Sanderson, William C.

AU - Kahn, RenéS

AU - van Praag, Herman M.

PY - 1992

Y1 - 1992

N2 - The relationship between norepinephrine (NE) and serotonin (5-hydroxytryptamine; 5HT) functioning was explored in a neuroendocrine challenge paradigm. Ten normal control subjects, 17 patients with major depression, and 22 patients with panic disorder volunteered to participate in this study. Each subject received a challenge with meta-chlorophenylpiperazine (MCPP; 0.25 mg/kg, p.o.), a 5HT agonist, and desmethylimipramine (DMI; 75 mg, i.m.), an indirect NE agonist, in randomized order. The peak-minus-baseline cortisol response to MCPP was used as an indicator of 5HT function, and cortisol response at 75 minutes-minus-baseline to DMI was used as an indicator of NE function. The cortisol responses to DMI and MCPP were found to be highly negatively correlated in the total sample, in particular in the patients with major depression and panic disorder. This findings suggests that the functions (or dysfunctions) of the NE and 5HT systems may not be separate as is usually believed, and that the NE and 5HT disturbances observed in major depression and panic disorder may not be independent. Rather, there may be a joint disturbance of NE-5HT in these disorders.

AB - The relationship between norepinephrine (NE) and serotonin (5-hydroxytryptamine; 5HT) functioning was explored in a neuroendocrine challenge paradigm. Ten normal control subjects, 17 patients with major depression, and 22 patients with panic disorder volunteered to participate in this study. Each subject received a challenge with meta-chlorophenylpiperazine (MCPP; 0.25 mg/kg, p.o.), a 5HT agonist, and desmethylimipramine (DMI; 75 mg, i.m.), an indirect NE agonist, in randomized order. The peak-minus-baseline cortisol response to MCPP was used as an indicator of 5HT function, and cortisol response at 75 minutes-minus-baseline to DMI was used as an indicator of NE function. The cortisol responses to DMI and MCPP were found to be highly negatively correlated in the total sample, in particular in the patients with major depression and panic disorder. This findings suggests that the functions (or dysfunctions) of the NE and 5HT systems may not be separate as is usually believed, and that the NE and 5HT disturbances observed in major depression and panic disorder may not be independent. Rather, there may be a joint disturbance of NE-5HT in these disorders.

KW - anxiety

KW - desmethylimipramine

KW - Major affective disorder

KW - meta-chlorophenylpiperazine

KW - psychoneuroendocrine challenges

UR - http://www.scopus.com/inward/record.url?scp=0026793388&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026793388&partnerID=8YFLogxK

U2 - 10.1016/0165-1781(92)90142-P

DO - 10.1016/0165-1781(92)90142-P

M3 - Article

VL - 43

SP - 65

EP - 76

JO - Psychiatry Research

JF - Psychiatry Research

SN - 0165-1781

IS - 1

ER -