Functional interaction between autophagy and ciliogenesis

Olatz Pampliega, Idil Orhon, Bindi Patel, Sunandini Sridhar, Antonio Díaz-Carretero, Isabelle Beau, Patrice Codogno, Birgit H. Satir, Peter Satir, Ana Maria Cuervo

Research output: Contribution to journalArticle

184 Citations (Scopus)

Abstract

Nutrient deprivation is a stimulus shared by both autophagy and the formation of primary cilia. The recently discovered role of primary cilia in nutrient sensing and signalling motivated us to explore the possible functional interactions between this signalling hub and autophagy. Here we show that part of the molecular machinery involved in ciliogenesis also participates in the early steps of the autophagic process. Signalling from the cilia, such as that from the Hedgehog pathway, induces autophagy by acting directly on essential autophagy-related proteins strategically located in the base of the cilium by ciliary trafficking proteins. Whereas abrogation of ciliogenesis partially inhibits autophagy, blockage of autophagy enhances primary cilia growth and cilia-associated signalling during normal nutritional conditions. We propose that basal autophagy regulates ciliary growth through the degradation of proteins required for intraflagellar transport. Compromised ability to activate the autophagic response may underlie some common ciliopathies.

Original languageEnglish (US)
Pages (from-to)194-200
Number of pages7
JournalNature
Volume502
Issue number7470
DOIs
StatePublished - 2013

Fingerprint

Cilia
Autophagy
Food
Protein Transport
Growth
Proteolysis

ASJC Scopus subject areas

  • General

Cite this

Pampliega, O., Orhon, I., Patel, B., Sridhar, S., Díaz-Carretero, A., Beau, I., ... Cuervo, A. M. (2013). Functional interaction between autophagy and ciliogenesis. Nature, 502(7470), 194-200. https://doi.org/10.1038/nature12639

Functional interaction between autophagy and ciliogenesis. / Pampliega, Olatz; Orhon, Idil; Patel, Bindi; Sridhar, Sunandini; Díaz-Carretero, Antonio; Beau, Isabelle; Codogno, Patrice; Satir, Birgit H.; Satir, Peter; Cuervo, Ana Maria.

In: Nature, Vol. 502, No. 7470, 2013, p. 194-200.

Research output: Contribution to journalArticle

Pampliega, O, Orhon, I, Patel, B, Sridhar, S, Díaz-Carretero, A, Beau, I, Codogno, P, Satir, BH, Satir, P & Cuervo, AM 2013, 'Functional interaction between autophagy and ciliogenesis', Nature, vol. 502, no. 7470, pp. 194-200. https://doi.org/10.1038/nature12639
Pampliega O, Orhon I, Patel B, Sridhar S, Díaz-Carretero A, Beau I et al. Functional interaction between autophagy and ciliogenesis. Nature. 2013;502(7470):194-200. https://doi.org/10.1038/nature12639
Pampliega, Olatz ; Orhon, Idil ; Patel, Bindi ; Sridhar, Sunandini ; Díaz-Carretero, Antonio ; Beau, Isabelle ; Codogno, Patrice ; Satir, Birgit H. ; Satir, Peter ; Cuervo, Ana Maria. / Functional interaction between autophagy and ciliogenesis. In: Nature. 2013 ; Vol. 502, No. 7470. pp. 194-200.
@article{f2567e0d6061473c8ca16384a8fef6d9,
title = "Functional interaction between autophagy and ciliogenesis",
abstract = "Nutrient deprivation is a stimulus shared by both autophagy and the formation of primary cilia. The recently discovered role of primary cilia in nutrient sensing and signalling motivated us to explore the possible functional interactions between this signalling hub and autophagy. Here we show that part of the molecular machinery involved in ciliogenesis also participates in the early steps of the autophagic process. Signalling from the cilia, such as that from the Hedgehog pathway, induces autophagy by acting directly on essential autophagy-related proteins strategically located in the base of the cilium by ciliary trafficking proteins. Whereas abrogation of ciliogenesis partially inhibits autophagy, blockage of autophagy enhances primary cilia growth and cilia-associated signalling during normal nutritional conditions. We propose that basal autophagy regulates ciliary growth through the degradation of proteins required for intraflagellar transport. Compromised ability to activate the autophagic response may underlie some common ciliopathies.",
author = "Olatz Pampliega and Idil Orhon and Bindi Patel and Sunandini Sridhar and Antonio D{\'i}az-Carretero and Isabelle Beau and Patrice Codogno and Satir, {Birgit H.} and Peter Satir and Cuervo, {Ana Maria}",
year = "2013",
doi = "10.1038/nature12639",
language = "English (US)",
volume = "502",
pages = "194--200",
journal = "Nature",
issn = "0028-0836",
publisher = "Nature Publishing Group",
number = "7470",

}

TY - JOUR

T1 - Functional interaction between autophagy and ciliogenesis

AU - Pampliega, Olatz

AU - Orhon, Idil

AU - Patel, Bindi

AU - Sridhar, Sunandini

AU - Díaz-Carretero, Antonio

AU - Beau, Isabelle

AU - Codogno, Patrice

AU - Satir, Birgit H.

AU - Satir, Peter

AU - Cuervo, Ana Maria

PY - 2013

Y1 - 2013

N2 - Nutrient deprivation is a stimulus shared by both autophagy and the formation of primary cilia. The recently discovered role of primary cilia in nutrient sensing and signalling motivated us to explore the possible functional interactions between this signalling hub and autophagy. Here we show that part of the molecular machinery involved in ciliogenesis also participates in the early steps of the autophagic process. Signalling from the cilia, such as that from the Hedgehog pathway, induces autophagy by acting directly on essential autophagy-related proteins strategically located in the base of the cilium by ciliary trafficking proteins. Whereas abrogation of ciliogenesis partially inhibits autophagy, blockage of autophagy enhances primary cilia growth and cilia-associated signalling during normal nutritional conditions. We propose that basal autophagy regulates ciliary growth through the degradation of proteins required for intraflagellar transport. Compromised ability to activate the autophagic response may underlie some common ciliopathies.

AB - Nutrient deprivation is a stimulus shared by both autophagy and the formation of primary cilia. The recently discovered role of primary cilia in nutrient sensing and signalling motivated us to explore the possible functional interactions between this signalling hub and autophagy. Here we show that part of the molecular machinery involved in ciliogenesis also participates in the early steps of the autophagic process. Signalling from the cilia, such as that from the Hedgehog pathway, induces autophagy by acting directly on essential autophagy-related proteins strategically located in the base of the cilium by ciliary trafficking proteins. Whereas abrogation of ciliogenesis partially inhibits autophagy, blockage of autophagy enhances primary cilia growth and cilia-associated signalling during normal nutritional conditions. We propose that basal autophagy regulates ciliary growth through the degradation of proteins required for intraflagellar transport. Compromised ability to activate the autophagic response may underlie some common ciliopathies.

UR - http://www.scopus.com/inward/record.url?scp=84885661260&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84885661260&partnerID=8YFLogxK

U2 - 10.1038/nature12639

DO - 10.1038/nature12639

M3 - Article

C2 - 24089209

AN - SCOPUS:84885661260

VL - 502

SP - 194

EP - 200

JO - Nature

JF - Nature

SN - 0028-0836

IS - 7470

ER -