@article{f2567e0d6061473c8ca16384a8fef6d9,
title = "Functional interaction between autophagy and ciliogenesis",
abstract = "Nutrient deprivation is a stimulus shared by both autophagy and the formation of primary cilia. The recently discovered role of primary cilia in nutrient sensing and signalling motivated us to explore the possible functional interactions between this signalling hub and autophagy. Here we show that part of the molecular machinery involved in ciliogenesis also participates in the early steps of the autophagic process. Signalling from the cilia, such as that from the Hedgehog pathway, induces autophagy by acting directly on essential autophagy-related proteins strategically located in the base of the cilium by ciliary trafficking proteins. Whereas abrogation of ciliogenesis partially inhibits autophagy, blockage of autophagy enhances primary cilia growth and cilia-associated signalling during normal nutritional conditions. We propose that basal autophagy regulates ciliary growth through the degradation of proteins required for intraflagellar transport. Compromised ability to activate the autophagic response may underlie some common ciliopathies.",
author = "Olatz Pampliega and Idil Orhon and Bindi Patel and Sunandini Sridhar and Antonio D{\'i}az-Carretero and Isabelle Beau and Patrice Codogno and Satir, {Birgit H.} and Peter Satir and Cuervo, {Ana Maria}",
note = "Funding Information: Acknowledgements We thank N. Mizushima and G. Pazour for providing MEFs and I. R. Veland and S. T. Christensen for providing the plasmid for expression of GFP– inversin. We also thank the personnel at the Analytical Imaging Facility for their technical assistance with TEM, J. Kraut and N. Rodriguez for their early assistance in cilia staining optimization and S. Kaushik for critically reviewing this manuscript. This work was supported bygrants from the NationalInstitute ofHealth NationalInstitute on Aging AG031782 and AG038072, National Institute of Diabetes and Digestive and Kidney Diseases DK098408 (to A.M.C.), Institut National de la Sant{\'e} et de la Recherche Medicale (to P.C. and I.B.), Institut National du Cancer and L{\textquoteright}Agence Nationale de la Recherche (to P.C.), and the generous support of Robert and Renee Belfer (to A.M.C.). O.P. was supported by a Basque Government Postdoctoral Fellowship.",
year = "2013",
doi = "10.1038/nature12639",
language = "English (US)",
volume = "502",
pages = "194--200",
journal = "Nature",
issn = "0028-0836",
publisher = "Nature Publishing Group",
number = "7470",
}