Functional integrity of the retrosplenial cortex is essential for rapid consolidation and recall of fear memory

Cynthia Katche, Guido Dorman, Leandro Slipczuk, Martín Cammarota, Jorge H. Medina

Research output: Contribution to journalArticlepeer-review

29 Scopus citations

Abstract

Memory storage is a temporally graded process involving different phases and different structures in the mammalian brain. Cortical plasticity is essential to store stable memories, but little is known regarding its involvement in memory processing. Here we show that fear memory consolidation requires early post-training macromolecular synthesis in the anterior part of the retrosplenial cortex (aRSC), and that reversible pharmacological inactivation of this cortical region impairs recall of recent as well as of remote memories. These results challenge the generally accepted idea that neocortical areas are slow encoding systems that participate in the retrieval of remote memories only.

Original languageEnglish (US)
Pages (from-to)170-173
Number of pages4
JournalLearning and Memory
Volume20
Issue number4
DOIs
StatePublished - Apr 2013

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Cognitive Neuroscience
  • Cellular and Molecular Neuroscience

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