Functional circuit architecture underlying parental behaviour

Johannes Kohl, Benedicte M. Babayan, Nimrod D. Rubinstein, Anita E. Autry-Dixon, Brenda Marin-Rodriguez, Vikrant Kapoor, Kazunari Miyamishi, Larry S. Zweifel, Liqun Luo, Naoshige Uchida, Catherine Dulac

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

Parenting is essential for the survival and wellbeing of mammalian offspring. However, we lack a circuit-level understanding of how distinct components of this behaviour are coordinated. Here we investigate how galanin-expressing neurons in the medial preoptic area (MPOAGal) of the hypothalamus coordinate motor, motivational, hormonal and social aspects of parenting in mice. These neurons integrate inputs from a large number of brain areas and the activation of these inputs depends on the animal's sex and reproductive state. Subsets of MPOAGal neurons form discrete pools that are defined by their projection sites. While the MPOAGal population is active during all episodes of parental behaviour, individual pools are tuned to characteristic aspects of parenting. Optogenetic manipulation of MPOAGal projections mirrors this specificity, affecting discrete parenting components. This functional organization, reminiscent of the control of motor sequences by pools of spinal cord neurons, provides a new model for how discrete elements of a social behaviour are generated at the circuit level.

Original languageEnglish (US)
Pages (from-to)326-331
Number of pages6
JournalNature
Volume556
Issue number7701
DOIs
StatePublished - Apr 19 2018
Externally publishedYes

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Neurons
Optogenetics
Galanin
Preoptic Area
Social Behavior
Hypothalamus
Spinal Cord
Brain
Population

ASJC Scopus subject areas

  • General

Cite this

Kohl, J., Babayan, B. M., Rubinstein, N. D., Autry-Dixon, A. E., Marin-Rodriguez, B., Kapoor, V., ... Dulac, C. (2018). Functional circuit architecture underlying parental behaviour. Nature, 556(7701), 326-331. https://doi.org/10.1038/s41586-018-0027-0

Functional circuit architecture underlying parental behaviour. / Kohl, Johannes; Babayan, Benedicte M.; Rubinstein, Nimrod D.; Autry-Dixon, Anita E.; Marin-Rodriguez, Brenda; Kapoor, Vikrant; Miyamishi, Kazunari; Zweifel, Larry S.; Luo, Liqun; Uchida, Naoshige; Dulac, Catherine.

In: Nature, Vol. 556, No. 7701, 19.04.2018, p. 326-331.

Research output: Contribution to journalArticle

Kohl, J, Babayan, BM, Rubinstein, ND, Autry-Dixon, AE, Marin-Rodriguez, B, Kapoor, V, Miyamishi, K, Zweifel, LS, Luo, L, Uchida, N & Dulac, C 2018, 'Functional circuit architecture underlying parental behaviour', Nature, vol. 556, no. 7701, pp. 326-331. https://doi.org/10.1038/s41586-018-0027-0
Kohl J, Babayan BM, Rubinstein ND, Autry-Dixon AE, Marin-Rodriguez B, Kapoor V et al. Functional circuit architecture underlying parental behaviour. Nature. 2018 Apr 19;556(7701):326-331. https://doi.org/10.1038/s41586-018-0027-0
Kohl, Johannes ; Babayan, Benedicte M. ; Rubinstein, Nimrod D. ; Autry-Dixon, Anita E. ; Marin-Rodriguez, Brenda ; Kapoor, Vikrant ; Miyamishi, Kazunari ; Zweifel, Larry S. ; Luo, Liqun ; Uchida, Naoshige ; Dulac, Catherine. / Functional circuit architecture underlying parental behaviour. In: Nature. 2018 ; Vol. 556, No. 7701. pp. 326-331.
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