Functional Changes in the Hemiplegic Upper Limb after Botulinum Toxin Type A Injection into One Elbow Flexor: Single-Blind Study

Jerry Y. Chao, Steve Flanagan, David Simpson, Jean-Michel Gracies

Research output: Contribution to conferenceAbstract

Abstract

OBJECTIVE: Evaluate functional changes after botulinum
toxin type-A (BTX-A) injections in a single upper limb muscle in spastic hemiplegia. METHODS: As part of a controlled
trial comparing three injection techniques of BTX-A
in spasticity, we used the Modified Frenchay Scale to assess
20 hemiplegic patients before and 1 month after an injection
of 160 units of BTX-A (Botox) into spastic biceps brachii.
Subjects were videotaped performing four unimanual and six
bimanual upper limb activities (picking up a cup, using a
comb, etc.). A blinded reviewer rated the performances on a
visual analog scale from 1 to 10. RESULTS: Functional performance
was significantly enhanced by a mean of 5% ( p
0.015; paired t-test). Mean improvement was 9% on unimanual
tasks ( p 0.06) and 2% on bimanual tasks (NS).
Individual task analysis showed significant improvement in
three tasks ( p 0.05), two of which were unimanual reaching
movements. CONCLUSION: A single injection of
BTX-A into biceps brachii was associated with upper limb
functional improvements in hemiparetic patients, particularly
in unimanual reaching activities. Functional scales using
blinded video assessments may be useful for detecting
changes after intervention in hemiplegia. Study supported by
Allergan. Jean-Michel Gracies received a research grant and
speaking honoraria from Allergan. David M. Simpson received
a research grant and speaking honoraria from Allergan.
Original languageEnglish (US)
PagesS72-S72
StatePublished - Aug 31 2004
EventAmerican Neurological Association: 2004 Annual Meeting - Toronto, Canada
Duration: Oct 3 2004Oct 6 2004

Conference

ConferenceAmerican Neurological Association: 2004 Annual Meeting
CountryCanada
CityToronto
Period10/3/0410/6/04

Fingerprint

Single-Blind Method
Type A Botulinum Toxins
Elbow
Upper Extremity
Hemiplegia
Organized Financing
Injections
Muscle Spasticity
Research
Muscles

Cite this

Chao, J. Y., Flanagan, S., Simpson, D., & Gracies, J-M. (2004). Functional Changes in the Hemiplegic Upper Limb after Botulinum Toxin Type A Injection into One Elbow Flexor: Single-Blind Study. S72-S72. Abstract from American Neurological Association: 2004 Annual Meeting, Toronto, Canada.

Functional Changes in the Hemiplegic Upper Limb after Botulinum Toxin Type A Injection into One Elbow Flexor: Single-Blind Study. / Chao, Jerry Y.; Flanagan, Steve; Simpson, David; Gracies, Jean-Michel.

2004. S72-S72 Abstract from American Neurological Association: 2004 Annual Meeting, Toronto, Canada.

Research output: Contribution to conferenceAbstract

Chao, JY, Flanagan, S, Simpson, D & Gracies, J-M 2004, 'Functional Changes in the Hemiplegic Upper Limb after Botulinum Toxin Type A Injection into One Elbow Flexor: Single-Blind Study' American Neurological Association: 2004 Annual Meeting, Toronto, Canada, 10/3/04 - 10/6/04, pp. S72-S72.
Chao JY, Flanagan S, Simpson D, Gracies J-M. Functional Changes in the Hemiplegic Upper Limb after Botulinum Toxin Type A Injection into One Elbow Flexor: Single-Blind Study. 2004. Abstract from American Neurological Association: 2004 Annual Meeting, Toronto, Canada.
Chao, Jerry Y. ; Flanagan, Steve ; Simpson, David ; Gracies, Jean-Michel. / Functional Changes in the Hemiplegic Upper Limb after Botulinum Toxin Type A Injection into One Elbow Flexor: Single-Blind Study. Abstract from American Neurological Association: 2004 Annual Meeting, Toronto, Canada.
@conference{1fa6aea34f2b4d3fbf24f8f02c72bea7,
title = "Functional Changes in the Hemiplegic Upper Limb after Botulinum Toxin Type A Injection into One Elbow Flexor: Single-Blind Study",
abstract = "OBJECTIVE: Evaluate functional changes after botulinumtoxin type-A (BTX-A) injections in a single upper limb muscle in spastic hemiplegia. METHODS: As part of a controlledtrial comparing three injection techniques of BTX-Ain spasticity, we used the Modified Frenchay Scale to assess20 hemiplegic patients before and 1 month after an injectionof 160 units of BTX-A (Botox) into spastic biceps brachii.Subjects were videotaped performing four unimanual and sixbimanual upper limb activities (picking up a cup, using acomb, etc.). A blinded reviewer rated the performances on avisual analog scale from 1 to 10. RESULTS: Functional performancewas significantly enhanced by a mean of 5{\%} ( p0.015; paired t-test). Mean improvement was 9{\%} on unimanualtasks ( p 0.06) and 2{\%} on bimanual tasks (NS).Individual task analysis showed significant improvement inthree tasks ( p 0.05), two of which were unimanual reachingmovements. CONCLUSION: A single injection ofBTX-A into biceps brachii was associated with upper limbfunctional improvements in hemiparetic patients, particularlyin unimanual reaching activities. Functional scales usingblinded video assessments may be useful for detectingchanges after intervention in hemiplegia. Study supported byAllergan. Jean-Michel Gracies received a research grant andspeaking honoraria from Allergan. David M. Simpson receiveda research grant and speaking honoraria from Allergan.",
author = "Chao, {Jerry Y.} and Steve Flanagan and David Simpson and Jean-Michel Gracies",
year = "2004",
month = "8",
day = "31",
language = "English (US)",
pages = "S72--S72",
note = "American Neurological Association: 2004 Annual Meeting ; Conference date: 03-10-2004 Through 06-10-2004",

}

TY - CONF

T1 - Functional Changes in the Hemiplegic Upper Limb after Botulinum Toxin Type A Injection into One Elbow Flexor: Single-Blind Study

AU - Chao, Jerry Y.

AU - Flanagan, Steve

AU - Simpson, David

AU - Gracies, Jean-Michel

PY - 2004/8/31

Y1 - 2004/8/31

N2 - OBJECTIVE: Evaluate functional changes after botulinumtoxin type-A (BTX-A) injections in a single upper limb muscle in spastic hemiplegia. METHODS: As part of a controlledtrial comparing three injection techniques of BTX-Ain spasticity, we used the Modified Frenchay Scale to assess20 hemiplegic patients before and 1 month after an injectionof 160 units of BTX-A (Botox) into spastic biceps brachii.Subjects were videotaped performing four unimanual and sixbimanual upper limb activities (picking up a cup, using acomb, etc.). A blinded reviewer rated the performances on avisual analog scale from 1 to 10. RESULTS: Functional performancewas significantly enhanced by a mean of 5% ( p0.015; paired t-test). Mean improvement was 9% on unimanualtasks ( p 0.06) and 2% on bimanual tasks (NS).Individual task analysis showed significant improvement inthree tasks ( p 0.05), two of which were unimanual reachingmovements. CONCLUSION: A single injection ofBTX-A into biceps brachii was associated with upper limbfunctional improvements in hemiparetic patients, particularlyin unimanual reaching activities. Functional scales usingblinded video assessments may be useful for detectingchanges after intervention in hemiplegia. Study supported byAllergan. Jean-Michel Gracies received a research grant andspeaking honoraria from Allergan. David M. Simpson receiveda research grant and speaking honoraria from Allergan.

AB - OBJECTIVE: Evaluate functional changes after botulinumtoxin type-A (BTX-A) injections in a single upper limb muscle in spastic hemiplegia. METHODS: As part of a controlledtrial comparing three injection techniques of BTX-Ain spasticity, we used the Modified Frenchay Scale to assess20 hemiplegic patients before and 1 month after an injectionof 160 units of BTX-A (Botox) into spastic biceps brachii.Subjects were videotaped performing four unimanual and sixbimanual upper limb activities (picking up a cup, using acomb, etc.). A blinded reviewer rated the performances on avisual analog scale from 1 to 10. RESULTS: Functional performancewas significantly enhanced by a mean of 5% ( p0.015; paired t-test). Mean improvement was 9% on unimanualtasks ( p 0.06) and 2% on bimanual tasks (NS).Individual task analysis showed significant improvement inthree tasks ( p 0.05), two of which were unimanual reachingmovements. CONCLUSION: A single injection ofBTX-A into biceps brachii was associated with upper limbfunctional improvements in hemiparetic patients, particularlyin unimanual reaching activities. Functional scales usingblinded video assessments may be useful for detectingchanges after intervention in hemiplegia. Study supported byAllergan. Jean-Michel Gracies received a research grant andspeaking honoraria from Allergan. David M. Simpson receiveda research grant and speaking honoraria from Allergan.

M3 - Abstract

SP - S72-S72

ER -