Functional activation during an auditory comprehension task in patients with temporal lobe lesions

D. C. Alsop, J. A. Detre, M. D'Esposito, R. S. Howard, J. A. Maldjian, M. Grossman, J. Listerud, E. S. Flamm, K. D. Judy, S. W. Atlas

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

Functional magnetic resonance imaging (fMRI) was used to map regional brain activation during an auditory comprehension task in two normal controls and two patients with left temporal lobe lesions. Activity in the superior temporal and angular gyrus regions was detected in all normal subjects. In the patients, the spatial distribution of activation ipsilateral to the lesions differed from the pattern observed in contralateral cortex or in control subjects. These studies highlight the potential of fMRI for mapping abnormal functional anatomy in the human brain.

Original languageEnglish (US)
Pages (from-to)55-59
Number of pages5
JournalNeuroImage
Volume4
Issue number1
DOIs
StatePublished - Aug 1996
Externally publishedYes

ASJC Scopus subject areas

  • Neurology
  • Cognitive Neuroscience

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    Alsop, D. C., Detre, J. A., D'Esposito, M., Howard, R. S., Maldjian, J. A., Grossman, M., Listerud, J., Flamm, E. S., Judy, K. D., & Atlas, S. W. (1996). Functional activation during an auditory comprehension task in patients with temporal lobe lesions. NeuroImage, 4(1), 55-59. https://doi.org/10.1006/nimg.1996.0028