Fulminant liver failure secondary to haemorrhagic dengue in an international traveller

James Gasperino, Jose Yunen, Alice Guh, Kathryn E. Tanaka, Vladimir Kvetan, Howard Doyle

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Dengue infections are caused by a single-stranded RNA virus, which has four serotypes (DEN 1-4); mosquitoes of the genus Aedes serve as vectors of transmission. Risk factors for dengue infection are related to both the host and virus. Age, gender, immune status, and genetic background of the host all contribute to the severity of dengue infection. Recently, international travel to endemic areas has also been identified as a major risk factor for both primary and secondary dengue infection. Dengue remains a diagnostic challenge, given its protean nature, ranging from mild febrile illness to profound shock. The most severe manifestation of dengue infection is dengue shock syndrome, which has an estimated mortality rate close to 50%. Dengue shock syndrome typically presents with increased anion gap metabolic acidosis, disseminated intravascular coagulation, severe hypotension, and jaundice. Liver involvement appears to occur more frequently when infections involve DEN-3 and DEN-4 serotypes. While hepatocellular damage has been reported previously in dengue infection, acute liver failure is an extremely rare occurrence in adults. We report a patient with dengue shock syndrome who presented with acute liver failure and hepatic encephalopathy after recent travel to an endemic area.

Original languageEnglish (US)
Pages (from-to)1148-1151
Number of pages4
JournalLiver International
Volume27
Issue number8
DOIs
StatePublished - Oct 2007

Fingerprint

Severe Dengue
Acute Liver Failure
Dengue
Infection
Hepatic Encephalopathy
Acid-Base Equilibrium
Aedes
Disseminated Intravascular Coagulation
RNA Viruses
Acidosis
Jaundice
Culicidae
Coinfection
Hypotension
Shock
Fever
Viruses
Mortality
Liver

Keywords

  • Dengue shock syndrome
  • Fulminantliver failure

ASJC Scopus subject areas

  • Hepatology

Cite this

Fulminant liver failure secondary to haemorrhagic dengue in an international traveller. / Gasperino, James; Yunen, Jose; Guh, Alice; Tanaka, Kathryn E.; Kvetan, Vladimir; Doyle, Howard.

In: Liver International, Vol. 27, No. 8, 10.2007, p. 1148-1151.

Research output: Contribution to journalArticle

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