FTO genotype, dietary protein, and change in appetite: The Preventing Overweight Using Novel Dietary Strategies trial

Tao Huang, Qibin Qi, Yanping Li, Frank B. Hu, George A. Bray, Frank M. Sacks, Donald A. Williamson, Lu Qi

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Background: A common obesity-risk variant rs9939609 in the fat mass- and obesity-associated (FTO) gene was recently shown to affect appetite, and the gene is sensitive to the regulation of amino acids. Objective: We examined the interaction between FTO genotype and protein intake on the long-term changes in appetite in a randomized controlled trial. Design: We genotyped FTO rs9939609 in 737 overweight adults in the 2-y Preventing Overweight Using Novel Dietary Strategies trial and assessed 4 appetite-related traits including cravings, fullness, hunger, and prospective consumption. Results: We showed that dietary protein significantly modified genetic effects on changes in food cravings and appetite scores at 6 mo after adjustment for age, sex, ethnicity, baseline body mass index, weight change, and baseline value for respective outcomes (P-interaction = 0.027 and 0.048, respectively). The A allele was associated with a greater decrease in food cravings and appetite scores in participants with high-protein-diet intake (P = 0.027 and 0.047, respectively) but not in subjects in the low-protein-diet group (P = 0.384 and 0.078, respectively). The weight regain from 6 to 24 mo attenuated gene-protein interactions. Protein intakes did not modify FTO genotype effects on other appetite measures. Conclusion: Our data suggest that individuals with the FTO rs9939609 A allele might obtain more benefits in a reduction of food cravings and appetite by choosing a hypocaloric and higher-protein weight-loss diet. This trial was registered at clinicaltrials.gov as NCT00072995.

Original languageEnglish (US)
Pages (from-to)1126-1130
Number of pages5
JournalAmerican Journal of Clinical Nutrition
Volume99
Issue number5
DOIs
StatePublished - May 1 2014
Externally publishedYes

Fingerprint

Dietary Proteins
Appetite
Obesity
Fats
Genotype
Food
Proteins
Alleles
Reducing Diet
Weights and Measures
Protein-Restricted Diet
Hunger
Genes
Body Mass Index
Randomized Controlled Trials
Diet
Amino Acids
Craving

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

FTO genotype, dietary protein, and change in appetite : The Preventing Overweight Using Novel Dietary Strategies trial. / Huang, Tao; Qi, Qibin; Li, Yanping; Hu, Frank B.; Bray, George A.; Sacks, Frank M.; Williamson, Donald A.; Qi, Lu.

In: American Journal of Clinical Nutrition, Vol. 99, No. 5, 01.05.2014, p. 1126-1130.

Research output: Contribution to journalArticle

Huang, Tao ; Qi, Qibin ; Li, Yanping ; Hu, Frank B. ; Bray, George A. ; Sacks, Frank M. ; Williamson, Donald A. ; Qi, Lu. / FTO genotype, dietary protein, and change in appetite : The Preventing Overweight Using Novel Dietary Strategies trial. In: American Journal of Clinical Nutrition. 2014 ; Vol. 99, No. 5. pp. 1126-1130.
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